Evidence map›Paper›PMID 41029900›Full record

ReviewBiophysical journal2025

Calcium dynamics in small spaces: Lessons learned from modeling in dendritic spines.

Kimberly J McCabe, María Hernández Mesa, Padmini Rangamani

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Biophysical journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Kimberly J McCabeDepartment of Computational Physiology, Simula Research Laboratory, Oslo, Norway.
María Hernández MesaDepartment of Computational Physiology, Simula Research Laboratory, Oslo, Norway.
Padmini RangamaniDepartment of Mechanical and Aerospace Engineering, Jacobs School of Engineering, University of California, San Diego, San Diego, California; Department of Pharmacology, School of Medicine, University of California, San Diego, San Diego, California. Electronic address: prangamani@ucsd.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Spatiotemporal dynamics of calcium regulation in subcellular regions is critical for precise local control of cell signaling. Recent studies have shown that, in addition to biochemical control of localized calcium signaling through buffers and channels, the geometry of the small spaces in which calcium signaling occurs also matters. Geometric organization becomes particularly important when considering the role of organelles such as the mitochondria and endoplasmic reticulum in regulating calcium signaling. Here, we discuss recent advances in our understanding of calcium dynamics in small spaces such as dendritic spines and how computational modeling can reveal a complex interplay between geometry and receptor clustering. We close with other biological examples where such interactions may be important and suggest the possibility of generalizable biophysical principles of localized calcium control.

Indexed as

CalciumDendritic SpinesModels, BiologicalAnimalsCalcium SignalingHumansCalcium

Identifiers

PMID41029900
PMCPMC12709433

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.