Trial reportJournal of health, population, and nutrition2025
Comparison the effect of continuous and bolus enteral nutrition methods on serum albumin and prealbumin in critical ill patients: A randomized clinical trial.
Trial report in Journal of health, population, and nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimsMechanically ventilated patients in intensive care units frequently require enteral nutrition. The choice of an appropriate feeding method may significantly influence nutritional status and clinical outcomes. Among biomarkers used for nutritional assessment, serum albumin, and prealbumin are widely accepted as reliable indicators for evaluating the effectiveness of nutritional interventions. This study aimed to compare the effects of two common enteral feeding methods-bolus and continuous feeding-on serum albumin and prealbumin levels in mechanically ventilated ICU patients.
methodsThis parallel, single-blind clinical trial was conducted at Imam Khomeini Hospital in Tehran, Iran, with 34 ICU patients receiving mechanical ventilation. Participants were randomly assigned to either the continuous feeding group (Intervention, n = 17) or the bolus feeding group (Control, n = 17). Enteral feeding was delivered via a nasogastric tube for one week. Serum albumin and prealbumin levels were measured before and one week after the intervention. Data were analyzed using SPSS version 16, and hypotheses were tested using paired and independent t-tests.
resultsNo significant changes were observed in serum albumin levels within or between the groups over the intervention period. However, patients in the continuous feeding group (Intervention group) showed a statistically significant increase in serum prealbumin levels (from 0.11 ± 0.06 to 0.15 ± 0.02 g/L, p = 0.004). In contrast, the change in the Bolus feeding group (Control group) was not significant (from 0.10 ± 0.04 to 0.12 ± 0.06 g/L, p = 0.39). The between-group comparison of post-intervention prealbumin levels approached significance in favor of the continuous feeding group (p = 0.08).
conclusionContinuous enteral feeding may have a positive effect on serum prealbumin levels in mechanically ventilated patients, while bolus feeding showed no such impact. However, due to the small sample size and short duration of the intervention, these findings should be interpreted cautiously. Further research with larger sample sizes and longer follow-ups is needed to confirm these results (Fig. 1).
trial registrationThe protocol of this clinical trial has been registered in the Iranian Clinical Trial Registration Center (registration code: IRCT20190128042528N1). Registered 18 January 2020- Retrospectively registered, date of first recruitment: 6 October 2018, https://www.irct.ir/ .
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.