ArticleInjury epidemiology2025
Investigation of the toxic dose of ingested delta-8 tetrahydrocannabinol among young children.
Article in Injury epidemiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIngestion of delta-8 tetrahydrocannabinol (Δ8THC) by young children is recognized as a public health concern and is commonly encountered by healthcare providers; however, a better understanding of Δ8THC toxicity in this age group is needed. The objective of this study is to investigate the relationship between body weight-based doses of ingested Δ8THC and clinical outcomes among children < 6 years old.
methodsUsing data from the National Poison Data System, we analyzed single-substance Δ8THC ingestions reported to United States poison centers to investigate the dose-response relationship between Δ8THC dose and clinical outcomes, including severe and prolonged toxicity, followed by receiver operator characteristic (ROC) curve analyses.
resultsThere were 232 cases (median age: 3.0 years, 51.7% female) and the median ingested Δ8THC dose was 6.7 mg/kg. CNS depression (75.5%) was the most common related clinical effect. There was a dose-response relationship between dose and CNS depression severity. Children who ingested a dose in the top quartile (> 17.0 mg/kg) had 3.43 times (95% CI: 1.44-8.14) greater odds of experiencing severe toxicity and 5.02 times (95% CI: 2.05-12.29) greater odds of prolonged toxicity than those who ingested a dose in the lowest quartile (< 2.4 mg/kg), with prolonged toxicity demonstrating a similar dose-response relationship. During ROC curve analyses, a dose cutoff of 2.3 mg/kg yielded a sensitivity of 91% with a specificity of 31% for identifying severe toxicity (area under the curve [AUC] = 0.64) and a sensitivity of 91% with a 37% specificity for identifying prolonged toxicity (AUC = 0.62). A dose cutoff of 1.7 mg/kg yielded a sensitivity of 98% with a specificity of 28% for identifying severe toxicity and a sensitivity of 93% with a 30% specificity for identifying prolonged toxicity.
conclusionsDespite limitations of NPDS data and inconsistent quality control and labeling of Δ8THC products, the findings of our study are similar to those previously described for delta-9 tetrahydrocannabinol ingestions among young children. We found that a 1.7 mg/kg dose cutoff value for Δ8THC had a high sensitivity for identifying severe or prolonged toxicity associated with Δ8THC ingestions among children < 6 years old; however, it was associated with a high number of false positives.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.