Evidence map›Paper›PMID 41029867›Full record

ArticleImplementation science : IS2025

The STop UNhealthy substance use now (STUN II) trial: protocol for a 48-site cluster randomized 2 × 2 factorial implementation trial to improve evidence-based screening and interventions for substance use disorder within primary care.

Daniel E Jonas, Seuli Bose Brill, Martin Fried, Leslie Brouwer, Sean Riley, Sarah R MacEwan, Madison Hyer, Marilly Palettas, Orman Trent Hall, Michael Vilensky and 4 more

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Implementation science : IS, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06524232 (The STop UNhealthy Substance Use Now Trial), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06524232 naactive not recruitingnot on this map

The STop UNhealthy Substance Use Now Trial

TypeinterventionalSponsorOhio State UniversityRan2024 to 2027Enrolled144ConditionsRisky Health Behavior, Substance Use Disorders, Substance Abuse, Alcohol Use DisorderArmsPractice Facilitation (PF), Learning Collaborative (LC), Performance Incentives (PI)
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Daniel E JonasDepartment of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA. Daniel.Jonas@osumc.edu.ORCID 0000-0003-1964-8731
Seuli Bose BrillDepartment of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Martin FriedDepartment of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Leslie BrouwerDepartment of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Sean RileyDepartment of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Sarah R MacEwanDepartment of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Madison HyerCenter for Biostatistics, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Marilly PalettasCenter for Biostatistics, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Orman Trent HallDepartment of Psychiatry and Behavioral Health, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Michael VilenskyDepartment of Psychiatry and Behavioral Health, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Julie TeaterDepartment of Psychiatry and Behavioral Health, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
William Felkel CarsonBehavioral Health, Bon Secours Mercy Health, Cincinnati, OH, USA.
Lai WeiCenter for Biostatistics, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Bryan R GarnerDepartment of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA.

Funding

AHRQ HHS R18 HS029782AHRQ HHS R18HS029782
6 · The paper itself

Abstract

backgroundDespite substance use disorders (SUD) being a leading cause of preventable death in the US, most people who visit primary care in the US are not screened for SUD. There are multiple barriers to screening for, identifying, and managing SUD in primary care. However, there are also promising strategies available to address these barriers, including practice facilitation (PF), learning collaboratives (LC), and performance incentives (PI).

methodsThis study is a 48-site cluster-randomized 2 × 2 factorial implementation trial that aims to compare the effectiveness of several strategies for implementing evidence-based screening and interventions for SUDs in primary care. Practices will be randomized to one of four implementation strategies: (1) PF only, (2) PF + LC, (3) PF + PI, or (4) all three strategies. An estimated 144 participants from 48 primary care practices will be enrolled. All participants will receive PF to guide them in making changes to implement screening for SUD, focusing on a defined change package and associated tools. PF includes quality improvement (QI) coaching, as well as electronic health record (EHR) support, training, and expert consultation. LC includes monthly virtual education sessions led by content experts to support practice improvement and innovation with didactics on key topics as well as facilitating participant interactions to share experiences. PI includes financial incentives for performance. Primary care practices will be the unit of analysis for both the primary outcome (rate of SUD screening) and secondary outcomes (rates of evidence-based interventions for SUD). Assessments will be conducted during a 12-month implementation phase and 12-month sustainment phase. DISCUSSION: This study will produce evidence regarding the comparative effectiveness of several strategies on implementation and sustainment of evidence-based screening and interventions for SUD within primary care. It will also generate knowledge about mechanisms of change in primary care settings. The results are expected to have a positive impact by providing a nuanced understanding of the incremental benefits of LC and/or PI to inform primary care practices, health systems, policymakers, and payers about optimal implementation strategies for SUD screening and evidence-based interventions.

trial registrationClinicalTrials.gov NCT06524232. July 23, 2024 -registered.

Indexed as

Mass ScreeningPrimary Health CareSubstance-Related DisordersHumansImplementation ScienceMulticenter Studies as TopicRandomized Controlled Trials as TopicUnited StatesCounselingImplementation scienceLearning collaborativePerformance incentivesPractice facilitationPrimary careScreeningSubstance use disorderUnhealthy alcohol useUnhealthy substance use

Identifiers

PMID41029867
PMCPMC12487228

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.