Trial reportBMC research notes2025
Gingival depigmentation by conservative injectable vitamin C in comparison with scalpel surgery: a randomized controlled split-mouth clinical trial.
Trial report in BMC research notes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Effectiveness of omega-3 poly unsaturated fatty acids on the treatment of gingival hyperpigmentation: a randomized controlled clinical trial.BMC oral health · 2026Trial
- Comparative evaluation of microneedling technique and diode laser in gingival depigmentation: A prospective randomized study.Journal of clinical and experimental dentistry · 2026Review
- Effectiveness of Vitamin C in managing gingival hyperpigmentation: A systematic review and meta-analysis.Journal of Indian Society of PeriodontologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGingival pigmentation (GP) is a common aesthetic concern in dentistry. While GP is not harmful, it can cause psychological distress. This study aimed to evaluate the efficacy of vitamin C injection for managing GP compared to the standard scalpel surgery.
methodsThe study involved 20 healthy patients aged 19-36. A randomized split-mouth design was used, with vitamin C injections (group 1) on one side and scalpel surgery (group 2) on the other side of the maxilla. Clinical evaluations of gingival depigmentation were conducted preoperatively and at first, second, three weeks and six months postoperatively, using the Gingival Pigmentation Index (GPI), Melanin Pigmentation Index (MPI), Dummett Oral Pigmentation Index (DOPI) and Color Intensity Analysis using ImageJ. Pain and patient satisfaction were measured with a visual analogue scale (VAS) after treatment.
resultsThe GPI, MPI, and DOPI showed no significant differences in pigmentation between the groups at baseline and after six months (P = 1.0 and 0.80 for GPI; P = 1.00 and 0.54 for MPI; P = 1.00 and 0.59 for DOPI). However, after three weeks, greater depigmentation was noted on the surgical side. The vitamin C group reported lower pain and itching levels (itch: P = 0.02; pain: P = 0.00).
trial registrationThis randomized controlled trial was retrospectively registered in the Thai Clinical Trial Registry at 05-7-2024 ( www.thaiclinicaltrials.org ), and its registration number is TCTR20240715003.
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