Trial reportBMC research notes2025
Effect of a patient-ventilator asynchrony (PVA) management protocol on treatment outcomes in ICU patients: a randomized controlled trial.
Trial report in BMC research notes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Consensus on identifying and ranking ventilator asynchronies in invasively ventilated ICU patients: a modified Delphi study (SYNAPsE).Intensive care medicine · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMechanical ventilation is a critical life support for ICU patients. However, this intervention can be associated with complications such as patient-ventilator asynchrony (PVA) and subsequent adverse events. This study aimed to investigate the impact of implementing a PVA management protocol on clinical outcomes in ICU patients.
methodsIn this single-blind randomized controlled trial conducted from January to August 2024, a total of 66 mechanically ventilated patients admitted to the ICU of a hospital affiliated with Ahvaz Jundishapur University of Medical Sciences (Ahvaz, Iran) were randomly allocated to either an intervention or control group using a permuted block randomization method. Patients in the intervention group were evaluated for patient-ventilator asynchrony (PVA) every two hours throughout their ICU stay, as long as they remained on mechanical ventilation. If PVA was detected, appropriate interventions were implemented in accordance with the protocol of PVA management. The control group received routine care without a specific PVA management protocol. Data were collected using a structured checklist and analyzed using SPSS version 22. This study registered in the Iranian Registry of Clinical Trials (IRCT20231001059572N1).
resultsThere was a significant difference between the intervention and control groups in terms of duration of mechanical ventilation (p < 0.001), length of ICU stay (p < 0.001), and successful weaning from the ventilator (p < 0.001). In all three dimensions, the intervention group showed better outcomes. However, there was no significant difference between the two groups in terms of ICU mortality (p = 0.202) and self-extubation (p = 0.787). Being in the intervention group was the strongest predictive factor for length of ICU stay (β = -8.268, p < 0.001) and duration of mechanical ventilation (β = -3.906, p = 0.003). No major harms or unintended adverse effects were reported related to the intervention.
conclusionImplementation of a PVA management protocol was associated with improved clinical outcomes, including reduced duration of mechanical ventilation, shorter ICU stays, and higher rates of successful weaning. Given its simplicity, cost-effectiveness, and the favorable results observed, broader adoption of this protocol in ICU settings is recommended. Further studies are warranted to confirm these findings and examine their generalizability across different clinical contexts.
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