ArticleBMC research notes2025
Human platelets support Semliki Forest virus replication.
Article in BMC research notes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Exploration of the expression and regulatory mechanisms of platelet miR-223-3p in hand, foot, and mouth disease (HFMD) complicated by encephalitis.Translational pediatrics · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivePlatelets are blood cells which are critical for effective haemostasis and thrombosis. Beyond these classic functions of platelets, a range of roles for them in infectious diseases have also emerged. However little is currently understood about platelet-virus interactions. This study was performed to assess if human platelets are permissive to, and support replication of Semliki Forest virus (SFV), a commonly used model alphavirus.
resultsUptake of the virus by washed human platelets was demonstrated with fluorescent flow cytometry using eGFP fused SFV. To explore if uptake of virus leads to transcriptional replication, RT-qPCR for SFV nsP4 was performed on platelets infected with SFV. This showed a significant increase in nsP4 RNA which increased further over time. This is the first demonstration of SFV RNA increasing within platelets and suggests that platelets may be able to support viral replication, however further work is required to clarify if this leads to production of functional virions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.