Evidence map›Paper›PMID 41029774›Full record

ArticleMolecular cytogenetics2025

Rare single PML::RARA fusion transcript from insertion on derivative chromosome 17 in acute promyelocytic leukemia.

Ping Yang, Daniel Cassidy, Catalina Amador, Sangeetha Venugopal

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular cytogenetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Atypical singleBlood neoplasia · 2026
    Article
  2. A novelFrontiers in oncology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ping YangDepartment of Pathology & Laboratory Medicine, UHealth System, University of Miami Miller School of Medicine, Miami, FL, USA. pxy111@med.miami.edu.
Daniel CassidyDepartment of Pathology & Laboratory Medicine, UHealth System, University of Miami Miller School of Medicine, Miami, FL, USA.
Catalina AmadorDepartment of Pathology & Laboratory Medicine, UHealth System, University of Miami Miller School of Medicine, Miami, FL, USA.
Sangeetha VenugopalDepartment of Medicine, Division of Hematology UHealth System, University of Miami Miller School of Medicine, Miami, FL, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Over 90% of patients with acute promyelocytic leukemia (APL) harbor the typical translocation characterized by the dual fusion of PML::RARA and RARA::PML transcripts. Here, we report a case with a single fusion of PML::RARA formed on der(17), without the RARA::PML fusion, and the patient responded well to all-trans-retinoic acid (ATRA) and arsenic trioxide (ATO) therapy. To our knowledge, this represents only the fourth reported case of this type. Our findings indicate that the PML::RARA fusion is the primary driver of APL leukemogenesis and the main therapeutic target for ATRA and ATO, suggesting that the RARA::PML transcript may not be essential for APL development.

Indexed as

Acute promyelocytic leukemia (APL)All-trans-retinoic acid (ATRA)Arsenic trioxide (ATO) therapyPML::RARA and RARA::PML transcripts

Identifiers

PMID41029774
PMCPMC12487051

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.