Evidence map›Paper›PMID 41029756›Full record

ArticleEuropean journal of medical research2025

CCDC137/DGCR8 axis promotes aerobic glycolysis in hepatocellular carcinoma via activation of the AKT/mTOR signaling pathway.

Zhiying Xu, Wei Shi, Jialun Ren, Qifei Zou, Mingming Fan, Yiran Li, Dong Jiang

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Article in European journal of medical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Zhiying Xu *Department of Hepatic Surgery IV, Shanghai Eastern Hepatobiliary Surgery Hospital, Third Affiliated Hospital of Naval Medical University, No. 201, Changhai Road, Shanghai, 200433, China.
Wei Shi *Department of General Surgery, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Jialun Ren *Department of Ultrasound, Eastern Hepatobiliary Surgery Hospital, The Third Affiliated Hospital of Naval Medical University, No. 201, Changhai Road, Shanghai, 200433, China.
Qifei ZouDepartment of Hepatic Surgery IV, Shanghai Eastern Hepatobiliary Surgery Hospital, Third Affiliated Hospital of Naval Medical University, No. 201, Changhai Road, Shanghai, 200433, China.
Mingming FanDepartment of Hepatic Surgery IV, Shanghai Eastern Hepatobiliary Surgery Hospital, Third Affiliated Hospital of Naval Medical University, No. 201, Changhai Road, Shanghai, 200433, China.
Yiran LiDepartment of Ultrasound, Eastern Hepatobiliary Surgery Hospital, The Third Affiliated Hospital of Naval Medical University, No. 201, Changhai Road, Shanghai, 200433, China. liyiranehsh@sina.com.
Dong JiangDepartment of Ultrasound, Eastern Hepatobiliary Surgery Hospital, The Third Affiliated Hospital of Naval Medical University, No. 201, Changhai Road, Shanghai, 200433, China. jiangdong2002317@aliyun.com.

Funding

Medical-engineering Interdisciplinary Research Youth Training Project 2022YGJC001National Natural Science Foundation of China Youth Training Project 2021GZR003
6 · The paper itself

Abstract

introductionHepatocellular carcinoma (HCC) is a leading cause of global cancer fatality. Understanding its molecular mechanisms is crucial for developing effective treatments.

methodsDifferentially expressed genes (DEGs) in the cancer genome atlas (TCGA)-liver hepatocellular carcinoma (LIHC) and GSE101685 data sets were analyzed using the "limma" tool in R. Weighted Gene Co-expression Network Analysis (WGCNA) identified the key turquoise module. Bioinformatics analyzed the prognostic significance and expression of CCDC137. Functional analyses assessed the effects of CCDC137 on cell behavior and tumor growth. The connection between CCDC137 and DGCR8 and their impact on the AKT/mTOR signaling pathway and glycolysis were also examined.

resultsA total of 670 overlapping DEGs were identified, and CCDC137, located within the turquoise module, was found to be significantly associated with HCC. CCDC137 was upregulated in HCC, correlating with worse prognostic outcomes. Experimental validation demonstrated that CCDC137 knockdown significantly reduced HCC cell proliferation, migration, invasion, and tumor growth. Mechanistically, CCDC137 may promote aerobic glycolysis through modulation of the AKT/mTOR signaling pathway, potentially mediated via its interaction with DGCR8.

conclusionsThese findings suggest that the CCDC137/DGCR8 axis may contribute to HCC progression by regulating cellular metabolism through the AKT/mTOR pathway. Targeting this regulatory network may offer a promising direction for future therapeutic exploration in HCC.

Indexed as

Carcinoma, HepatocellularLiver NeoplasmsProto-Oncogene Proteins c-aktRNA-Binding ProteinsTOR Serine-Threonine KinasesAnimalsCell Line, TumorCell ProliferationGene Expression Regulation, NeoplasticGlycolysisHumansMicePrognosisSignal TransductionMTOR protein, humanProto-Oncogene Proteins c-aktRNA-Binding ProteinsTOR Serine-Threonine KinasesAerobic glycolysisAKT/mTOR signaling pathwayCCDC137DGCR8Hepatocellular carcinoma

Identifiers

PMID41029756
PMCPMC12486682

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.