Evidence map›Paper›PMID 41029738›Full record

ArticleBMC medical genomics2025

Exploration and validation of the immune-related genes signatures and potential molecular mechanisms shared between Alzheimer's disease (AD) and Parkinson's disease (PD).

Kaige Zhou, Jingxing Zhang, Junhui Su, Weifang Tong, Ruoyu Li, Xuerui Xiang, Lingjing Jin, Yunping Song

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PubMed Full text at PMC Publisher
In one paragraph

Article in BMC medical genomics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Kaige ZhouDepartment of Neurology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200092, China.
Jingxing ZhangDepartment of Neurology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200092, China.
Junhui SuDepartment of Neurology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200092, China.
Weifang TongDepartment of Neurology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200092, China.
Ruoyu LiDepartment of Neurology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200092, China.
Xuerui XiangDepartment of Neurology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200092, China.
Lingjing JinDepartment of Neurology and Neurological Rehabilitation, Shanghai Disabled Persons' Federation Key Laboratory of Intelligent Rehabilitation Assistive Devices and Technologies, Yangzhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center), School of Medicine, Tongji University, Shanghai, 200092, China. lingjingjin@163.com.
Yunping SongDepartment of Neurology and Neurological Rehabilitation, Shanghai Disabled Persons' Federation Key Laboratory of Intelligent Rehabilitation Assistive Devices and Technologies, Yangzhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center), School of Medicine, Tongji University, Shanghai, 200092, China. igosong@hotmail.com.

Funding

Ganquan Outstanding Youth Fund HBRC2105National Natural Science Foundation of China 81901301National Natural Science Foundation of China 82172545Shanghai Research Center of Rehabilitation Medicine( Top Priority Research Center of Shanghai) 2023ZZ02027Shanghai Yangzhi Rehabilitation Hospital KYPT202202Sunshine Program for Clinical Research Incubation funded by Shanghai Yangzhi Rehabilitation Hospital 2024CRZD010
6 · The paper itself

Abstract

backgroundAlzheimer’s disease (AD) and Parkinson’s disease (PD) share neuroinflammatory features, yet their common immune-related mechanisms remain unclear.

methodsWe integrated microarray datasets from AD/PD brain tissues to identify immune-related genes (IRGs). Hub genes were prioritized via protein-protein interaction (PPI) networks and validated using a Parkinson’s dementia (PDD) cohort and AD/PD mouse models. Functional enrichment, immune cell infiltration, and TF-miRNA networks were analyzed.

resultsEleven hub IRGs (CXCR4, FLT1, SLIT1/2, SEMA3G/6D, etc.) were identified. CXCR4 and FLT1 exhibited significant upregulation in AD/PD patient brain tissues (AUC > 0.7, adjusted p-value of <0.05) and mouse model brain tissues (p < 0.05), correlating with cytokine signaling and axon guidance pathways. CXCR4 is uniquely associated with resting memory CD4+ T cells in both diseases, while FLT1 showed disease-specific immune interactions. A TF-miRNA network (39 TFs, 22 miRNAs) implicated CREB1 and STAT1/3 as key regulators.

conclusionCXCR4 and FLT1 are pivotal shared immune hubs in AD/PD, linked to T-cell dysregulation and neuroinflammation. These findings highlight potential therapeutic targets and biomarkers for neurodegenerative comorbidity.

Indexed as

Alzheimer DiseaseParkinson DiseaseAnimalsBrainGene Expression ProfilingGene Regulatory NetworksHumansMiceMicroRNAsProtein Interaction MapsReceptors, CXCR4MicroRNAsReceptors, CXCR4Alzheimer’s diseaseCXCR4FLT1Immune-related mechanismsParkinson’s disease

Identifiers

PMID41029738
PMCPMC12481742

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.