ArticleBMC chemistry2025
Green extraction of poplar type propolis: ultrasonic extraction parameters and optimization via response surface methodology.
Article in BMC chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Optimizing the extraction of natural products is an important step to obtain products rich in bioactive compounds with less energy use and costs. The aim of this study was to optimize the ultrasonic extraction process of poplar type propolis with natural deep eutectic solvent (NADES) citric acid:1,2-propanediol 1:4 (CAPD 1:4). Based on preliminary experiments, the extraction parameters solvent to solid ratio, temperature, and time were found to have a strong positive effect on the extraction of phenolic compounds, and they were further optimized by response surface methodology (RSM) via the Box-Behnken design (BBD). Solvent to solid ratio of 30 mL/g, ultrasonication time of 39 min and temperature of 65 °C were determined as optimum conditions for the highest values of total phenolic content (TPC, 290.35 mg/g), total flavones and flavonols content (TFC, 89.48 mg/g) and radical scavenging activity (31.89%RSA). The optimized extract was analyzed by gas chromatography-mass spectrometry (GC-MS) and a high relative content of valuable propolis constituents was found such as pinocembrin, 3-acetylpinobanksin, chrysin, galangin and phenethyl caffeate (CAPE). The results provide knowledge about optimal conditions for the development of a greener extract of poplar type propolis rich in valuable bioactive compounds with potential application in cosmetic, nutraceutical and pharmaceutical industries.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.