Evidence map›Paper›PMID 41029722›Full record

ArticleMicrobial cell factories2025

Effect of different colloidal gold nanomaterials on Ganoderma lingzhi fermentation for production of ganoderma polysaccharide and triterpenoid through macroscopic and microscopic investigation.

Mengqiu Luo, Muling Shi, Yang Li, Yiqing Yang, Hanqi Wei, Shengwen Luo, Wenhuan Huang, Yida Deng, Gao-Qiang Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbial cell factories, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mengqiu Luo *Key Laboratory of Pico Electron Microscopy of Hainan Province, School of Materials Science and Engineering, State Key Laboratory of Tropic Ocean Engineering Materials and Materials Evaluation, Hainan University, Haikou, 570228, Hainan Province, China.
Muling Shi *Key Laboratory of Pico Electron Microscopy of Hainan Province, School of Materials Science and Engineering, State Key Laboratory of Tropic Ocean Engineering Materials and Materials Evaluation, Hainan University, Haikou, 570228, Hainan Province, China. mulingshi@hnu.edu.cn.
Yang LiKey Laboratory of Pico Electron Microscopy of Hainan Province, School of Materials Science and Engineering, State Key Laboratory of Tropic Ocean Engineering Materials and Materials Evaluation, Hainan University, Haikou, 570228, Hainan Province, China.
Yiqing YangHunan Provincial Key Laboratory of Forestry Biotechnology, College of Life Science and Technology, Central South University of Forestry & Technology, Changsha, 410004, Hunan Province, China.
Hanqi WeiKey Laboratory of Pico Electron Microscopy of Hainan Province, School of Materials Science and Engineering, State Key Laboratory of Tropic Ocean Engineering Materials and Materials Evaluation, Hainan University, Haikou, 570228, Hainan Province, China.
Shengwen LuoKey Laboratory of Pico Electron Microscopy of Hainan Province, School of Materials Science and Engineering, State Key Laboratory of Tropic Ocean Engineering Materials and Materials Evaluation, Hainan University, Haikou, 570228, Hainan Province, China.
Wenhuan HuangHunan Provincial Key Laboratory of Forestry Biotechnology, College of Life Science and Technology, Central South University of Forestry & Technology, Changsha, 410004, Hunan Province, China.
Yida DengKey Laboratory of Pico Electron Microscopy of Hainan Province, School of Materials Science and Engineering, State Key Laboratory of Tropic Ocean Engineering Materials and Materials Evaluation, Hainan University, Haikou, 570228, Hainan Province, China. yd_deng@hainanu.edu.cn.
Gao-Qiang LiuHunan Provincial Key Laboratory of Forestry Biotechnology, College of Life Science and Technology, Central South University of Forestry & Technology, Changsha, 410004, Hunan Province, China. gaoliuedu@csuft.edu.cn.

Funding

Hainan Provincial Natural Science Foundation of China grant number 823QN228Key Research and Development Project of Hainan Province ZDYF2025GXJS005 and ZDYF2024GXJS006National Natural Science Foundation of China 52231008the China Postdoctoral Science Foundation grant number 2020M682536the Education Department of Hainan Province grant number Hnjg2023-15
6 · The paper itself

Abstract

Ganoderma lingzhi (G. lingzhi) is a Basidiomycete macrofungus valued for its secondary metabolites with pharmacological activity. To enhance the biosynthesis of secondary metabolites, various exogenous additives have been introduced to fungal fermentation processes. Metal nanomaterials, while known to influence cellular metabolism in mammalian systems, exhibit unclear effects when applied to macrofungal cultivation systems. The study systematically evaluates the impact of three distinct gold nanostructures-nanoparticles (AuNPs), nanorods (AuNRs), and nanoclusters (AuNCs)-on bioactive metabolite production during G. lingzhi submerged fermentation, employing integrated macroscopic process analytics and microscopic characterization. The results demonstrate that their impact on mycelial growth and bioactive metabolite production varied with the type, concentration, and addition timing of gold nanomaterials. Microscopic survey on cell surface morphology and nanoparticle distribution also reveals the different patterns of nanomaterial-mycelia cell interaction. Under the optimized addition conditions, AuNPs increased total polysaccharide content by 50.37% compared to the control group, while AuNRs increased triterpenoid content by 42.78%. The work confirms the potential of colloidal gold nanomaterials to facilitate the submerged fermentation of G. lingzhi, which is expected to encourage the development of nanomaterial additives-based approach for efficient microbial bioactive substances production.

Indexed as

GanodermaGoldGold ColloidMetal NanoparticlesPolysaccharidesTriterpenesFermentationMyceliumNanotubesGoldGold ColloidPolysaccharidesTriterpenesFungiGold nanomaterialsPolysaccharideScanning electronic microscopySubmerged fermentationTriterpenoid

Identifiers

PMID41029722
PMCPMC12487537

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.