ReviewChinese medicine2025
Berberine-based strategies: novel delivery systems bring out new potential for wound healing.
Review in Chinese medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Berberine-Pretreated Bone Marrow Mesenchymal Stem Cells Accelerate Skin Wound Healing in Rats With Burn Injuries.International wound journal · 2026Article
- Plant-Based Therapeutics Against Communicable Diseases: A Review of Ethnopharmacology and Medicinal Chemistry Approaches.Chemistry & biodiversity · 2026Review
- A Biomimetic NAC-Loaded PCL/Modified Chitosan/dECM Fibrous Scaffold for Accelerating Diabetic Wound Healing and Minimizing Scarring.Polymers · 2026Article
- Berberine Interferes with the Molecular Landscape of Biofilm-Driven Pathogenicity.Pathogens (Basel, Switzerland) · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Wound healing is a highly regulated biological process that restores tissue integrity following injury, while it could be disrupted in specific conditions such as diabetes mellitus (DM) and bacterial infection, leading to delayed healing and serious complications. Berberine (BBR) is a pivotal naturally occurring isoquinoline alkaloid with multiple pharmacological activities, especially anti-inflammation, anti-bacteria, anti-oxidative stress, which are beneficial for wound healing. Recently, various novel carrier materials such as hydrogel scaffold, nanofiber membrane, and nanoparticles with specific pH, temperature, glucose, ROS, near infrared light responsive and controlled release properties have been utilized as carries to improve the bioactive and bioavailability of BBR that bring out promising therapeutic effect on acute wound, diabetic wound, infected wound, and burned wound. In this review, the design, synthesis, and application of novel delivery systems loaded/based with BBR were summarized based on the characteristics of these smart materials. Remarkably, the action of BBR delivery systems on wound healing are highlighted, with the aim of promoting the development of innovative materials for drug delivery in wound healing, particularly under chronic conditions in clinic.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.