Observational studyBMC pulmonary medicine2025
Association between BRINDA-corrected iron metabolism and lung function in the community: the CoLaus|PneumoLaus study.
Observational study in BMC pulmonary medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Small airways dysfunction: associated factors, clinical aspects and new perspectives.European respiratory review : an official journal of the European Respiratory Society · 2026Review
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIron metabolism and its relationship to lung volumes remains poorly understood, with inconsistent findings reported across the literature. We analysed the association of markers of inflammation and iron metabolism with lung function in a large population-based cohort.
methodsPneumoLaus is a sub-study of CoLaus|PsyCoLaus, an ongoing prospective observational study conducted in Lausanne, Switzerland. Within PneumoLaus, participants performed spirometry and blood sampling at two time points (baseline, 2014-2017; follow-up (FU), 2018-2021). The associations between ferritin and transferrin using BRINDA correction with spirometric values were assessed by Pearson correlation. We performed multivariable linear regressions using spirometry values as dependent variable adjusted for main confounders.
results3102 (women, 56%) and 1989 (women, 55%) participants were included at baseline and FU, respectively. In both surveys, ferritin levels were not associated with FEV1, FVC and MMEF, even using the adjusted model. A weak negative association was observed only at FU in women with FEV1 and FVC. In both surveys, transferrin was negatively associated with FEV1 and FVC (standardised β coefficients -0.061 to -0.102, p < 0.001) in all subjects and in women. In the adjusted model, FEV1 is reduced by 47 to 59 mL and FVC by 63 to 71 mL for 1-SD increase of transferrin levels. Transferrin saturation was not associated with spirometric values.
conclusionsIn this population-based cohort, we observed no reproductible association between ferritin levels and spirometric values. However, transferrin levels were negatively associated with FEV1 and FVC, suggesting that iron metabolism, particularly the requirement for iron in the organism, is linked to reduced lung volumes.
trial registrationNot required. This study is not a clinical trial. This is a population based observational study. The approval number reference 16/03 13403,13405bis, 134052to5 addenda 1to4. For other approvals, see the section dedicated to page 26 and 27.
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