Evidence map›Paper›PMID 41029621›Full record

ArticleBMC public health2025

Barriers to malaria prevention services in pregnancy: a multi-methods study in rural western Uganda.

Rachel A Clubine Horowitz, Herbert Ngelese, Emmanuel Baguma, Grace Nyangoma, Bwambale Shem, Moses Ntaro, Edgar M Mulogo, Ross M Boyce

Abstract read
In one paragraph

Article in BMC public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Rachel A Clubine HorowitzDepartment of Public Health, Davidson College, Davidson, NC, 28035, USA. rachel.clubinehorowitz@gwmail.gwu.edu.
Herbert NgeleseDepartment of Community Health, Faculty of Medicine, Mbarara University of Science & Technology, Mbarara, Uganda.
Emmanuel BagumaDepartment of Community Health, Faculty of Medicine, Mbarara University of Science & Technology, Mbarara, Uganda.
Grace NyangomaBugoye Level III Health Center, Uganda Ministry of Health, Bugoye, Kasese District, Uganda.
Bwambale ShemBugoye Level III Health Center, Uganda Ministry of Health, Bugoye, Kasese District, Uganda.
Moses NtaroDepartment of Community Health, Faculty of Medicine, Mbarara University of Science & Technology, Mbarara, Uganda.
Edgar M MulogoDepartment of Community Health, Faculty of Medicine, Mbarara University of Science & Technology, Mbarara, Uganda.
Ross M BoyceInstitute for Global Health and Infectious Diseases, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.

Funding

Re-Entry Supplement: Investigation of Oral Microbial Enzymes for the Detection and Treatment of Periodontal DiseaseUL1TR002489 · NCATS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BUSE, JOHN BERNARD, SHAHEEN, NICHOLAS J · 2018 to 2022
$48.6M
North Carolina Translational and Clinical Sciences Institute (NC TraCS)UM1TR004406 · NCATS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI NICHOLAS J SHAHEEN · 2023 to 2026
$37.5M
Serial Killers to Mosquitos: The Spatial Targeting of Larval habitats in rural Uganda using geographic ProfilingK23AI141764 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BOYCE, ROSS MATHEW · 2019 to 2023
$944k
NCATS NIH HHS UL1 TR002489NCATS NIH HHS UL1TR002489NCATS NIH HHS UM1 TR004406NIAID NIH HHS K23 AI141764Weyerhaeuser Family Foundation K23AI141764
6 · The paper itself

Abstract

backgroundMalaria in pregnancy (MiP) remains a substantial public health problem, accounting for a large proportion of adverse outcomes for both mothers and developing child in endemic areas. Although interventions such as intermittent preventive treatment in pregnancy (IPTp) have been shown to be effective, uptake remains suboptimal. This study aimed to identify factors associated with MiP among pregnant women at their initial antenatal visit and to explore perceptions of MiP among both midwives and pregnant women in the community to identify barriers to the utilization of available prevention services.

methodsPregnant women attending their first antenatal clinic visit at one of four lower-level health facilities were screened for Plasmodium falciparum malaria using a rapid diagnostic test. Demographic characteristics and clinical measures were documented on case report forms to assess associations with the malaria test result. Quantitative findings informed focus group discussions with pregnant women and individual semi-structured interviews with midwives at each facility.

resultsFrom February 2021 to September 2022, 1,644 pregnant women underwent testing for malaria. A total of 225 (13.5%) had a positive rapid diagnostic test (RDT) result. Primigravid status and younger maternal age were associated with malaria positivity. In the qualitative arm, stakeholders identified the following risk factors and barriers regarding MiP: (i) delayed testing for pregnancy and MiP, (ii) fear or hesitancy of chemoprevention, (iii) financial constraints, (iv) transportation barriers, (v) antenatal clinic operations, (vi) low bed net use, (vii) knowledge gaps, (viii) and attitudes of spouses.

conclusionYoung, primigravid women remain at the highest risk of MiP in rural western Uganda. Although consistent with findings from other regions, the impact of geographic barriers that may delay pregnancy testing and initiation of antenatal care merit further study. Approaches to decentralize services further into the community may be particularly beneficial.

Indexed as

Health Services AccessibilityMalariaMalaria, FalciparumPregnancy Complications, ParasiticRural PopulationAdolescentAdultFemaleFocus GroupsHumansPatient Acceptance of Health CarePregnancyPrenatal CareUgandaYoung AdultMalariaMalaria in pregnancyMulti-methodsPlasmodiumUganda

Identifiers

PMID41029621
PMCPMC12487232

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.