A rare case of isovaleric acidemia and schizophrenia: a case report.

Jiawei Zhou, Hui Chen, Xianliang Chen, Huajia Tang, Sihong Li, Jiansong Zhou

Abstract readCase Reports

In one paragraph

Article in BMC psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jiawei ZhouDepartment of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders, The Second Xiangya Hospital of Central South University, No. 139 Middle Renmin Road, Changsha, Hunan, 410011, China.

Hui ChenDepartment of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders, The Second Xiangya Hospital of Central South University, No. 139 Middle Renmin Road, Changsha, Hunan, 410011, China.

Xianliang ChenDepartment of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders, The Second Xiangya Hospital of Central South University, No. 139 Middle Renmin Road, Changsha, Hunan, 410011, China.

Huajia TangDepartment of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders, The Second Xiangya Hospital of Central South University, No. 139 Middle Renmin Road, Changsha, Hunan, 410011, China.

Sihong LiDepartment of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders, The Second Xiangya Hospital of Central South University, No. 139 Middle Renmin Road, Changsha, Hunan, 410011, China.

Jiansong ZhouDepartment of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders, The Second Xiangya Hospital of Central South University, No. 139 Middle Renmin Road, Changsha, Hunan, 410011, China. zhoujs2003@csu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSchizophrenia is a severe chronic mental disorder characterized by hallucinations, delusions, and disorganized speech and behavior. On the other hand, isovaleric acidemia (IVA) is a rare metabolic disorder characterized by the accumulation of isovaleric acid and its metabolic byproducts in the body. To date, there is a notable absence of clinical descriptions concerning the simultaneous occurrence of IVA and schizophrenia in the existing literature. CASE PRESENTATION: This report presents a clinical case involving the coexistence of IVA and Schizophrenia. A 25-year-old male patient diagnosed with comorbid IVA and schizophrenia was admitted to the psychiatric department due to worsening delusions and auditory hallucinations. Treatment with antipsychotics (clozapine 150 mg/day and blonanserin 24 mg/day) and metabolic agents (L-carnitine 3 g/day and reduced glutathione 1.2 g/day) reduced delusion severity, though delusions persisted, while auditory hallucinations resolved.

conclusionsIn this case description, the authors describe a rare clinical case in which the patient presents with IVA and schizophrenia. This case discusses the potential pathways through which IVA may precipitate the onset of schizophrenia.

Indexed as

Amino Acid Metabolism, Inborn ErrorsSchizophreniaAdultAntipsychotic AgentsDelusionsHallucinationsHumansIsovaleryl-CoA DehydrogenaseMaleAntipsychotic AgentsIsovaleryl-CoA DehydrogenaseComorbidityEtiologyIsovaleric acidemiaRare diseaseSchizophrenia

Identifiers

PMID41029572

DOI10.1186/s12888-025-07239-8

PMCPMC12487407

What OpenQuestion holds

Textmetadata

LicenceCC BY-NC-ND

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.