ArticleBMC cancer2025
The correlation between postoperative hypouricemia and postoperative complications in patients with gastrointestinal cancer: a retrospective nested case-control study.
Article in BMC cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveThis study aimed to investigate the dynamics of serum uric acid (sUA) during gastrointestinal cancer surgery. This study aimed to determine the correlation between postoperative hypouricemia and surgical complications.
methodsThis retrospective nested case-control study was conducted using data from 708 patients with gastrointestinal cancer (2018-2020) at a tertiary hospital. Postoperative complications were stratified using the Clavien-Dindo system. Through 1:1 propensity score matching (age ± 2 years, sex), 149 complication cases were matched to 149 controls. Serial sUA measurements were analyzed preoperatively (D
resultsThe cohort (mean age 60.0 ± 10.5 years) demonstrated a 21.05% complication rate (15.54% severe). Case group exhibited significantly lower sUA levels at all timepoints (D
conclusionPostoperative sUA decline correlates with the postoperative complication risk in gastrointestinal cancer surgery. Postoperative sUA level may have the ability to predict the occurrence of postoperative complications, suggesting that sUA monitoring could enhance postoperative surveillance strategies. However, further research is needed to confirm this association and evaluate its clinical utility.
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