ArticleBMC psychiatry2025
Influence of TPH2 DNA methylation and family functioning, parenting styles on OCD severity.
Article in BMC psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe etiology of obsessive-compulsive disorder (OCD) is multifactorial and remains incompletely understood. While both the Tryptophan hydroxylase 2 (TPH2) gene and the family environment have been implicated in OCD, few studies have examined their combined effects. This study aimed to investigate the association between TPH2 DNA methylation and family functioning and parenting styles in patients with OCD.
methodA total of 58 individuals with OCD and 89 age- and gender- matched healthy controls were recruited. DNA methylation levels at 12 CpG sites in the promoter region of TPH2 were quantified using the MassARRAY system. OCD symptom severity was assessed using the Yale-Brown Obsessive Compulsive Scale (Y-BOCS). Parenting styles and family functioning were evaluated using the Egna Minnen Barndoms Uppfostran (EMBU) and Family Assessment Device (FAD), respectively.
results(1) Methylation at CpG site 6 was significantly associated with OCD status in a binary logistic regression model and remained significant after Bonferroni correction. (2) In the OCD group, CpG sites 2 and 1/3/8 showed negative correlations with the 'general functioning' and 'roles' subscales of the FAD, respectively, while CpG site 7 was positively correlated with 'affective involvement'. Methylation levels at CpG sites 2, 4, 5, 9 and 10 significantly differed based on the presence or absence of specific parenting styles in EMBU. (3) Regarding symptom severity, methylation at CpG sites 6, 9 and 12, as well as FAD dimensions (problem-solving, communication, affective responsiveness, general functioning), father's punishment, and mother's preference, were significantly associated with Y-BOCS scores.
conclusionDNA methylation at specific CpG sites in the TPH2 promoter region may play a critical role in the pathogenesis and symptom severity of OCD. Methylation patterns also correlated with family functioning and parenting styles. These findings suggest that TPH2 methylation may mediate the link between adverse family environments and OCD, possibly through reduced serotonin synthesis and impaired emotion regulation. Our results support a gene-environment interaction model contributing to OCD vulnerability.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.