ArticleBMC ophthalmology2025
Identification of aberrantly expressed circular RNAs in choroidal neovascularization in mice.
Article in BMC ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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7 authors.
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Abstract
backgroundTo show the representation profile and potential functions of circular RNAs (circRNAs) in a mouse model of choroidal neovascularization (CNV).
methodsIn one CNV mouse model, circRNA expression profiles were determined through microarray analysis. Selected altered circRNAs were validated by qRT-PCR. In addition to a KEGG analysis, gene ontology (GO) enrichment was implemented to measure signaling pathways, as well as biological functions. CircRNA/miRNA interactions were forecast using TargetScan and miRana programs. Choroidal flatmounts and qRT-PCR were then implemented in an attempt to examine the function of circRNA_0000273 in macrophage polarization and CNV formation.
resultsThis study found that 134 circRNAs were differentially expressed within the CNV mouse model (P< 0.05, fold change > 1.5). Their host genes were found to be involved in cellular component organization (ontology: biologic reaction), organelles (ontology: cell component), and protein binding (ontology: molecular function). The mRNAs expressed with circRNAs were largely engaged in the JAK2-STAT3 signaling pathway. CircRNA_0000273 was significantly increased in M2 macrophages. Moreover, the inhibition of circRNA_0000273 was found to suppress M2 macrophage gene expression and CNV formation in the laser-induced mouse model.
conclusionsCircRNAs are involved in CNV pathogenesis, and circRNA_0000273 is an underlying target for CNV prevention and therapy.
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