Evidence map›Paper›PMID 41029520›Full record

ArticleBMC pregnancy and childbirth2025

Association of spontaneous abortion with dietary folate intake in individuals with different genotypes of FTO gene.

Golsa Khalatbari Mohseni, Mahsa Shapouri, Sheyda Nami, Zahra Mousavi, Niloufar Pourmalek Lahiji, Zahra Mahmoudi, Mohadeseh Sadat Mousavi Hoseini, Zahra Saeedirad, Ali Shamsi-Goushki, Soheila Shekari and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC pregnancy and childbirth, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Golsa Khalatbari MohseniNutrition and Metabolic Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Mahsa ShapouriDepartment of Clinical Nutrition, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Sheyda NamiIran University of medical sciences, Tehran, Iran.
Zahra MousaviNursing and Midwifery, Shahed University, Tehran, Iran.
Niloufar Pourmalek LahijiDepartment of Medicine, Faculty of Sciences, Guilan University, Rasht, Iran.
Zahra MahmoudiStudent Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran.
Mohadeseh Sadat Mousavi HoseiniDepartment of Food Industry Engineering, Padova University, Padova, Italy.
Zahra SaeediradDepartment of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Ali Shamsi-GoushkiDepartment of Nutrition, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Soheila ShekariNutrition and Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Bojlul BaharDepartment of Sport Science and Nutrition, Maynooth University, Maynooth, Ireland.
Barbod AlhoueiDepartment of Community Nutrition, School of Nutrition and Food Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Saeid DoaeiDepartment of Obstetrics and Gynecology, Reproductive Health Research Center, Al-Zahra Hospital, Guilan University of Medical Sciences, Rasht, Iran. sdoaee@yahoo.com.
Mitra RezaeiGenomic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. m.rezaie@sbmu.ac.ir.
Maryam GholamalizadehNational Nutrition and Food Technology Research Institute, Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundResearch has revealed a possible connection between dietary folate intake and the risk of spontaneous abortion (SA). Interestingly, the FTO gene may play a dual role, influencing both folate needs and SA susceptibility. Therefore, this research sought to investigate the interaction between FTO genotypes, dietary folate intake, and the potential risk of SA.

methodsThis case-control study was conducted on 539 adult women, including 192 women with a history of SA and 347 women without a history of abortion. To evaluate FTO gene genotypes for the presence of rs9939609 polymorphism, 5 ml of blood was collected from all participants. A validated semi-quantitative food frequency questionnaire (FFQ) was used to assess the dietary folate intake. Binomial logistic regression was used to investigate the relationship between folate intake and SA in carriers of different FTO genotypes.

resultsA negative association was found between dietary folate intake and SA, especially in females with the AA genotype of FTO rs9939609 polymorphism (OR = 0.97, 95% CI 0.95-0.99, P = 0.04). The statistical significance of this link persisted even after adjusting for age, body mass index (BMI), drinking alcohol, smoking, and dietary intake.

conclusionsThis study indicates that dietary folate intake may protect against SA, particularly in women who have the FTO rs9939609 polymorphism. However, more investigation is required to confirm these findings and elucidate the underlying mechanisms linking SA, the FTO gene, and folate intake.

Indexed as

Abortion, SpontaneousAlpha-Ketoglutarate-Dependent Dioxygenase FTODietFolic AcidAdultCase-Control StudiesFemaleGenetic Predisposition to DiseaseGenotypeHumansPolymorphism, Single NucleotidePregnancyRisk FactorsYoung AdultAlpha-Ketoglutarate-Dependent Dioxygenase FTOFolic AcidFTO protein, humanDietary folate intakeGenotypes of FTO genePregnancySpontaneous abortion

Identifiers

PMID41029520
PMCPMC12487378

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.