Evidence map›Paper›PMID 41029398›Full record

ArticleJournal of health, population, and nutrition2025

The association between digestion-resistant and bioactive peptide content of dairy products and bladder cancer: a case-control study.

Atiyeh Sadat Hosseini, Seyyed Mostafa Jalali, Zainab Shateri, Marzieh Shoja, Milad Rajabzadeh-Dehkordi, Maede Makhtoomi, Melika Hajjar, Bahram Rashidkhani, Mehran Nouri

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Article in Journal of health, population, and nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Atiyeh Sadat HosseiniFaculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Seyyed Mostafa JalaliFaculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Zainab ShateriDepartment of Nutrition and Biochemistry, School of Medicine, Ilam University of Medical Sciences, Ilam, Iran.
Marzieh ShojaNutrition and Metabolic Diseases Research Center and Clinical Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Milad Rajabzadeh-DehkordiStudent Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran.
Maede MakhtoomiStudent Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran.
Melika HajjarDepartment of Community Nutrition, School of Nutrition Sciences and Food Technology), Student Research Committee (National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Bahram RashidkhaniDepartment of Community Nutrition, Faculty of Nutrition and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran. rashidkhani@yahoo.com.
Mehran NouriInfertility and Reproductive Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran. mehran_nouri71@yahoo.com.ORCID 0000-0002-7031-3542

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBladder cancer is the sixth most common cancer worldwide. Bioactive peptides (BP) are digestion-resistant (enzymatically stable) and absorbable fragments that exert physiological functions in the body. We conducted this case-control study to examine the association between dairy-derived BPs and bladder cancer.

methodsThe present case-control study (103 cases and 200 controls) was a hospital-based investigation conducted in three referral hospitals in Tehran, Iran. Dietary intake was assessed using a validated 168-item Food Frequency Questionnaire (FFQ). Intake of BPs was estimated based on dairy product consumption recorded in the FFQ. Logistic regression analysis was used to examine the association between the content of digestion-resistant BPs in dairy products and the odds of bladder cancer.

resultsAfter adjusting confounding factors, it was observed that the odds of bladder cancer were significantly lower in the second and last tertiles (T) of total peptide intake from dairy products compared to the first tertile (T

conclusionsThe findings suggest a potential inverse relationship between milk-derived BPs and bladder cancer risk, which warrants further investigation in longitudinal or interventional studies. However, further studies are needed to elucidate the biological properties and mechanism of action of milk-derived BPs.

Indexed as

Dairy ProductsDietDigestionPeptidesUrinary Bladder NeoplasmsAdultAgedCase-Control StudiesFemaleHumansIranLogistic ModelsMaleMiddle AgedOdds RatioRisk FactorsPeptidesBioactive peptideBladder cancerDairy products

Identifiers

PMID41029398
PMCPMC12486994

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