Observational studyBMC research notes2025
Neutrophil extracellular traps as a predictive biomarker for severe Mycoplasma pneumonia in children: a clinical observational study.
Observational study in BMC research notes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed.
- Associations of Serum CIRP and CXCL5 With Prognosis and Neutrophil Extracellular Traps in Pediatric Mycoplasma pneumoniae Pneumonia.The clinical respiratory journal · 2026Article
- East Asia as a sentinel: risk-stratified corticosteroid therapy for paediatric macrolide-resistantEuropean respiratory review : an official journal of the European Respiratory Society · 2026Review
- Neutrophil extracellular traps biomarkers are associated with lung function obstruction severity in bronchial asthma.The Journal of international medical research · 2026Article
- Neutrophil extracellular traps and severe mycoplasma pneumonia: A clinical observational study.Medicine · 2026Observational
- Article
- The value of serum CARDS toxin and NETs formation in children with MPP.Frontiers in cellular and infection microbiology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
objectiveThis study aims to evaluate the association between NETs levels and SMPP severity.
methodsFrom January 2023 to August 2024, we selected children hospitalized with mycoplasma pneumonia (MPP). They were divided into two groups: a non-severe group (MPP group, n = 100) and a severe group (SMPP group, n = 50). ELISA was used to detect the concentration of NETs in the serum of both groups. Bronchoalveolar lavage fluid (BALF) was collected from the affected and unaffected lungs of children in the SMPP group, and ELISA was used to measure the concentration of NETs in BALF.
resultsThere was a statistically significant difference in the concentration of NETs in the serum between the MPP and SMPP groups (P < 0.01). The concentration of NETs in the BALF of the affected lung in the SMPP group was higher than that in the intact lung (P < 0.001). The concentration of NETs in the serum of the SMPP group was higher than that in BALF (P < 0.001). The area under the receiver operating characteristic curve (ROC ) for serum NETs predicting SMPP was 0.820 (95% CI 0.760–0.884, P < 0.001), with a sensitivity of 0.821 and specificity of 0.845, and a cutoff value of 18.50 ng/mL. The ROC AUC for predicting SMPP using serum NETs combined with C-reactive protein (CRP) and lactate dehydrogenase (LDH) was 0.894 (95% CI 0.845–0.942, P < 0.001), with a sensitivity of 0.883 and specificity of 0.820.
conclusionOveractivated NETs in children with MPP may be related to the occurrence of SMPP.
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Registered trials
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