ArticleBMC complementary medicine and therapies2025
An investigation on anti-biofilm potential of Aegle marmelos fruit extract against multi-drug-resistant Staphylococcus aureus.
Article in BMC complementary medicine and therapies, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundStaphylococcus aureus, member of ESKAPEE pathogens is a noteworthy contributor to the global crisis rising due to antimicrobial resistance. Biofilms are the primary reason behind the increased antibiotic resistance and tolerance of pathogens. Hence targeting bacterial biofilms has been prioritized as an alternative strategy to counter antibiotic resistance. Aegle marmelos has gained prominence in Indian traditional medicine as seeds, fruits, leaves, bark and roots of this plant are being in use extensively in treating several kinds of ailments by the inhabitants of this subcontinent due to its ethno-pharmacological relevance. The fruit of this plant has been found with remarkable anti-bacterial properties along with other therapeutic efficacies. The present study aimed to identify the anti-biofilm potential of methanolic fruit extract of Aegle marmelos (AMFE) against multi-drug-resistant (MDR) S. aureus strains as a resort to counter the global crisis of antimicrobial resistance for alternative approaches.
resultsMBIC and MBEC of AMFE ranged between 100 and 200 µg.mL
conclusionAnti-biofilm activity of AMFE towards MDR S. aureus have been established through in vitro biochemical and gene expression studies that were further substantiated by microscopic studies which reveal that AMFE could be explored in the management of S. aureus-associated infections.
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