ArticleBMC pulmonary medicine2025
Chemoradiotherapy versus radiotherapy in patients with stage T1-2N0M0 small cell lung cancer: a retrospective cohort study.
Article in BMC pulmonary medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeTo compare survival outcomes between chemoradiotherapy versus radiotherapy in patients with stage T1-2N0M0 small cell lung cancer (SCLC). MATERIALS AND
methodsSCLC patients from the Surveillance, Epidemiology, and End Results databases between 2000 and 2020 were investigated. Kaplan-Meier survival analysis was employed to assess cancer-specific survival (CSS) and overall survival (OS).
resultsAmong 525 eligible patients, 371 (70.7%) received chemoradiotherapy, 64 (12.2%) underwent radiotherapy, and 90 (17.1%) received chemotherapy. While 5-year SCLC-specific mortality rates were comparable between chemoradiotherapy and radiotherapy groups (57.1% vs. 51.8%, P = 0.660), non-cancer mortality demonstrated significant reduction with chemoradiotherapy (13.3% vs. 30.2%, P = 0.004). After propensity score matching, median CSS was 27 months with chemoradiotherapy versus 26 months with radiotherapy (hazard ratio [HR] = 0.93, 95% confidence interval [CI]: 0.57-1.52; P = 0.787). Multivariable analysis confirmed radiotherapy was not an independent prognostic factor for CSS (HR = 0.85, 95% CI: 0.52-1.41; P = 0.532). Median OS was 21.5 months for chemoradiotherapy and 20 months for radiotherapy (HR = 1.11, 95% CI: 0.76-1.64; P = 0.586). Multivariable analysis confirmed radiotherapy was not an independent prognostic factor for OS (HR = 1.03, 95% CI: 0.69-1.54; P = 0.888).
conclusionRadiotherapy demonstrates comparable survival outcomes to chemoradiotherapy in stage T1-2N0M0 SCLC patients.
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