ArticleBMC public health2025
Obesity as the predominant contributor to asthma burden: insights from GBD and NHANES analyses.
Article in BMC public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effectiveness of Metabolic and Bariatric Surgery for Patients with Obesity and Asthma: A Systematic Review and Meta-Analysis.Obesity surgery · 2026Pooled it
- Global Asthma Disparities: Deciphering the Multifaceted Environmental Exposome Between Eastern and Western Populations.Clinical reviews in allergy & immunology · 2026Review
- Edentulism in China and the Group of Twenty (G20): Epidemiological Trends, Decomposition Analysis, and Forecasts to 2038.International dental journal · 2026Article
- Global, regional, and national burden of chronic obstructive pulmonary disease and asthma from 1990 to present: risk attributions and projections to 2050.Internal and emergency medicine · 2026Article
- Global ecological associations between overweight/obesity and non-communicable disease prevalence among children aged 5-9 years: a sex-stratified analysis of 174 countries.Frontiers in public health · 2026Article
- Inflammatory Dysregulation, Asthma, and Obesity in Children: What is the Relationship?Journal of inflammation research · 2026Review
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7 authors.
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Abstract
objectiveThis study describes the global asthma burden trends from 1990 to 2021 and identifies key risk factors contributing to changes in asthma burden, focusing on the impact of obesity on asthma burden.
methodsWe extracted asthma incidence, mortality, and Disability-Adjusted Life Years (DALYs) from the Global Burden of Disease (GBD) database (1990-2021), stratifying by age, sex and Socio-demographic Index (SDI). Temporal trends were evaluated using Joinpoint regression. Decomposition analysis quantified contributions of population growth, aging, and age-specific rates to DALY changes. Frontier analysis evaluated SDI regions' effectiveness in reducing asthma burden. To evaluate the impact of obesity, we further analyzed risk-attributable DALYs and, using National Health and Nutrition Examination Survey (NHANES) data (2021-2023), performed multivariable logistic regression examining associations between body-mass index (BMI) and asthma outcomes.
resultsAlthough age-standardized incidence and mortality rates declined, asthma remained prevalent in 2021 with an estimated 37 million new cases and 21.4 million DALYs, disproportionately affecting children (0-14 years) and older adults (55-74 years). Decomposition analysis attributed most DALY increases to demographic changes, particularly population growth and aging. Frontier analysis showed that while high-SDI regions achieved notable reductions in burden, rising obesity rates expanded the at-risk population even in these areas. High BMI emerged as the leading global risk factor for asthma-related DALYs-ranking first in high-SDI regions and, since the late 2010s, in low-SDI regions as well. NHANES analyses confirmed that individuals with asthma exhibited significantly higher BMI (Non- Asthma: 29.4 ± 7.32, Asthma: 31.2 ± 8.48, P < 0.001) Adjusted regression demonstrated that obesity independently predicted asthma onset and progression across all age groups (BMI Adjusted Odds Ratio (aOR): 1.41; 95% confidence interval (CI): 1.17-1.68.)
conclusionDespite declines in standardized rates, asthma continues to impose a heavy global burden, concentrated in vulnerable age groups, especially among the young and elderly. Obesity has emerged as the foremost modifiable risk factor worldwide. Tailored public health strategies focusing on weight management are urgently needed to curb asthma incidence and severity.
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