Evidence map›Paper›PMID 41029249›Full record

ArticleBMC cancer2025

Preoperative HBsAg seroclearance affects long-term outcomes for hepatitis B virus-related hepatocellular carcinoma after liver resection: a multicenter analysis.

Si-Yu Liu, Lin Zhu, Wen-Feng Lu, Gui-Lin Xie, Lei Liang, Jun-Wei Liu, Bin Ye, Mu-Gen Dai

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

8 authors.

Si-Yu Liu *Department of Laboratory Medicine, The Key Laboratory of Imaging Diagnosis and Minimally Invasive Interventional Research of Zhejiang Province, The Fifth Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, China.
Lin Zhu *Department of Gastroenterology, Wenzhou Medical University, Wenzhou, Zhejiang Province, China.
Wen-Feng Lu *Department of Hepatobiliary Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University (Navy Medical University), Shanghai, China.
Gui-Lin XieDepartment of Hepatobiliary Surgery, Affiliated Hospital of Shaoxing University, Shaoxing, Zhejiang Province, China.
Lei LiangGeneral Surgery, Cancer Center, Department of Hepatobiliary & Pancreatic Surgery and Minimally Invasive Surgery, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang Province, China.
Jun-Wei LiuGeneral Surgery, Cancer Center, Department of Hepatobiliary & Pancreatic Surgery and Minimally Invasive Surgery, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang Province, China.
Bin YeDepartment of Gastroenterology, Wenzhou Medical University, Wenzhou, Zhejiang Province, China. 408252097@qq.com.
Mu-Gen DaiDepartment of Gastroenterology, The Fifth Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, China. daimg2008@163.com.

Funding

the public welfare technology application research projects from the Science and Technology Bureau of Lishui No. 2022GYX50the public welfare technology application research projects from the Science and Technology Bureau of Lishui No. 2023GYX42the study was provided by the Natural Science Foundation of Zhejiang Province No. LQ23H160049
6 · The paper itself

Abstract

BACKGROUND &

aimsWe aimed to investigate the impact of HBsAg seroclearance on the long-term prognosis of HBV-related HCC following curative liver resection.

methodsPatients treated with curative-intent hepatectomy for HBV-related HCC in 4 Chinese hospitals were enrolled. Patients were stratified into HBsAg-positive and HBsAg-seroclearance groups. Overall survival (OS) and time-to-recurrence (TTR) were compared between HBsAg-positive and HBsAg-seroclearance patients using propensity score matching (PSM). Independent risk factors of OS, cancer-specific survival (CCS) and TTR were identified by univariable and multivariable Cox regression and competing risk regression analyses.

resultsAmong 1008 HBV-related HCC patients, 81 (8.0%) patients achieved HBsAg seroclearance before surgery. Patients in HBsAg-seroclearance groups had better liver function reserve. Postoperative morbidity was comparable between the two groups before and after PSM. In the entire cohort, the Kaplan-Meier curves showed that HBsAg-seroclearance patients had better OS (p = 0.022) and TTR (p < 0.001). However, there was no significant difference between the two groups of patients regarding OS (p = 0.134) in the PSM cohort. Multivariable Cox regression and competing risk regression analyses demonstrated that HBsAg seroclearance was independently associated with lower TTR (p < 0.05), but not with better OS and CSS (p > 0.05).

conclusionsPreoperative HBsAg seroclearance is associated with a lower risk of TTR for HBV-related HCC among patients undergoing curative hepatectomy.

Indexed as

Carcinoma, HepatocellularHepatectomyHepatitis BHepatitis B Surface AntigensLiver NeoplasmsAdultAgedFemaleHepatitis B virusHumansKaplan-Meier EstimateMaleMiddle AgedNeoplasm Recurrence, LocalPrognosisRetrospective StudiesHepatitis B Surface AntigensHBsAg seroclearanceHepatectomyHepatitis B virusRecurrenceSurvival

Identifiers

PMID41029249
PMCPMC12481949

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.