Evidence map›Paper›PMID 41029181›Full record

ArticleJournal of neonatal-perinatal medicine2026

Machine learning demonstrates normal fetal Doppler velocimetry associated with reduced risk of necrotizing enterocolitis among preterm infants with growth restriction.

F Kim, K E Joung, H Field, M Garland, A Lyford, J J Sheen, T Hays

Abstract read
In one paragraph

Article in Journal of neonatal-perinatal medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

F KimDivision of Neonatology, Department of Pediatrics, NewYork Presbyterian Morgan Stanley Children's Hospital/Columbia University Medical Center, NewYork, NY, USA.ORCID 0000-0002-0344-0613
K E JoungDivision of Neonatology, Department of Pediatrics, NewYork Presbyterian Morgan Stanley Children's Hospital/Columbia University Medical Center, NewYork, NY, USA.ORCID 0000-0002-5942-4241
H FieldDivision of Neonatology, Department of Pediatrics, NewYork Presbyterian Morgan Stanley Children's Hospital/Columbia University Medical Center, NewYork, NY, USA.
M GarlandDivision of Neonatology, Department of Pediatrics, NewYork Presbyterian Morgan Stanley Children's Hospital/Columbia University Medical Center, NewYork, NY, USA.
A LyfordDepartment of Statistics, Middlebury College, Middlebury, VT, USA.ORCID 0000-0001-6742-0198
J J SheenDivision of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Columbia University Irving Medical Center, NewYork, NY, USA.
T HaysDivision of Neonatology, Department of Pediatrics, NewYork Presbyterian Morgan Stanley Children's Hospital/Columbia University Medical Center, NewYork, NY, USA.ORCID 0000-0002-3705-8973

Funding

Clinical and Translational Science AwardUL1TR001873 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI REILLY, MUREDACH P · 2016 to 2025
$99.0M
The Genetic Basis of Morbidity and Mortality in Small for Gestational Age Preterm InfantsK23HD113827 · NICHD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Thomas Hays · 2023 to 2026
$666k
NCATS NIH HHS UL1 TR001873NICHD NIH HHS K23 HD113827
6 · The paper itself

Abstract

BackgroundNecrotizing enterocolitis (NEC) is an intestinal ischemic disease that affects preterm infants with fetal growth restriction (FGR). The role of fetal Dopplers in stratifying risk for developing NEC is unclear but the innovative use of machine learning technology may aid in identifying their contribution.MethodsThis is a single center retrospective cohort of 164 infants born before 33 weeks' gestation with FGR from 2016 to 2019. We used machine learning to classify NEC and to evaluate the predictive values of gestational age (GA), birth weight (BW), and the presence of abnormal umbilical artery (UA) Dopplers before delivery.ResultsEarly GA and lower BW strongly predicted NEC. The presence of normal fetal UA Dopplers was heavily weighted in classifying infants unlikely to develop NEC. Fetal UA Dopplers had a 95% specificity (15% sensitivity) for NEC.ConclusionsIf validated, normal fetal UA Doppler studies may identify infants with FGR at low risk for NEC who may avoid conservative NEC-prevention strategies.

Indexed as

Enterocolitis, NecrotizingFetal Growth RetardationMachine LearningUltrasonography, DopplerUltrasonography, PrenatalUmbilical ArteriesBirth WeightFemaleGestational AgeHumansInfant, NewbornInfant, PrematureMalePredictive Value of TestsPregnancyRetrospective Studiesfetal growth restrictionmachine learningnecrotizing enterocolitispreterm

Identifiers

PMID41029181
PMCPMC12797851

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.