Observational studyMedicine2025
The effectiveness of the ketogenic diet in treating refractory epilepsy: A study of different seizure forms.
Observational study in Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Effects of switching from a high-fat diet to a ketogenic diet on oxidative stress, nitrosative damage, and protein glycation in rat skin.Frontiers in immunology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
The objective of this study was to compare the efficacy of the ketogenic diet (KD) in patients with refractory epilepsy with different seizure forms and to further evaluate the correlation between seizure types and the efficacy of KD. In this prospective observational cohort study, consecutive children with refractory epilepsy (N = 72) treated with KD were recruited for follow-up. The children were divided into 2 groups: a nongeneralized seizure group and a full seizure group. Monthly seizure frequencies and seizure reduction rate after KDT 3 months and 6 months were compared between 2 groups. Follow-up results at 3 and 6 months showed a decrease in seizure frequency in both the nonprolific and full seizure groups, and the differences in seizure frequency from baseline were statistically significant in both the nonprolific and full seizure groups. After 3 months of KD treatment, the seizure frequency in the nongeneralized seizure group was notably lower than that in the full seizure group. However, after 6 months of KD treatment, there was no statistically significant difference between the seizure frequency of patients in the nongeneralized seizure group and those in the full seizure group. Further findings indicated a greater proportion of seizure reduction in the nongeneralized seizure group than in the full seizure group after 3 months of KD treatment. Statistically significant differences exist between the 2 groups (P＜.05). At the 6 months mark of KD treatment, no statistically significant disparities were observed in the seizure. Finally, this paper further proves the above point by comparing the number of patients who responded to KD through per-protocol population (PP) analysis and intention-to-treat analysis.
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Registered trials
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