ArticleMedicine2025
The causal effects of genetically predicted sex hormone-binding globulin and sarcopenia: A 2-sample Mendelian randomization study.
Article in Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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9 authors.
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Abstract
Observational studies suggest a link between sex hormone-binding globulin (SHBG) and sarcopenia, but the causal relationship is unclear. We conducted a 2-sample Mendelian randomization (MR) study using genome-wide association studies summary data to explore the causal associations between SHBG and traits of sarcopenia, including appendicular lean mass, hand grip strength, and walking pace. Our primary method was inverse-variance weighted, supplemented by weighted median, weighted mode, and MR-Egger regression. Horizontal pleiotropy was assessed using MR-Egger and Mendelian randomization-Pleiotropy Residual Sum and Outlier, with a leave-one-out analysis for robustness. Inverse-variance weighted results showed that there was a causal relationship between genetically predicted SHBG and usual walking pace (odds ratio = 1.04057, 95% confidence interval: 1.01542-1.06635, P = .00144). The results of our study indicate a causal association between SHBG and sarcopenia. Further research is required to confirm these observations and better understand the underlying mechanisms linking SHBG to sarcopenia.
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