Observational studyMedicine2025
Exploring therapeutic targets of curcumin for knee osteoarthritis via the gene-gut microbiota-plasma metabolite axis: An observational study.
Observational study in Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors.
Funding
Abstract
Osteoarthritis (OA) is a prevalent, chronic, degenerative joint disorder characterized by a multifaceted pathogenesis. Conventional risk variables inadequately account for its evolution, leading to heightened focus on systemic causes. Dysbiosis of gut microbiota associated with immunological, metabolic, and inflammatory abnormalities, can influence joint health through the "gut-joint axis." This study investigated the correlation between OA and gut microbiota dysbiosis to identify novel therapeutic targets. This study utilized 211 gut microbiota characteristics as exposures, 1400 plasma metabolite concentrations as mediators, and Genome-Wide Association Study (GWAS) data for patients with knee osteoarthritis (KOA) as outcomes. Mendelian randomization (MR) analyses were performed via inverse variance weighting, with robustness verified using pleiotropy and heterogeneity assessments. We identified the intersection of differentially expressed genes from the transcriptome analysis of OA patients with genes exhibiting significant causal associations derived from MR analysis. The intersecting genes were then analyzed through Kyoto Encyclopedia of Genes and Genomes (KEGG) and gene ontology enrichment analysis, as well as molecular docking and molecular dynamics simulations. Our analyses indicated that the Lachnospiraceae family, genus UCG001, exhibited a negative correlation with KOA, potentially mitigating the condition by reducing the glycine-to-serine ratio. Sensitivity analyses validated the robustness of these associations. Reverse Mendelian randomization analyses (rMRa) provided no evidence of reverse causality. The integration of GWAS and Gene Expression Omnibus (GEO) data revealed that 1 gene had a substantial association with KOA, suggesting it as a potential therapeutic target for KOA. Molecular docking analysis and molecular dynamics simulations were employed to forecast potential drug-target interactions, therefore substantiating the therapeutic potential of curcumin. Our study provides insights into the development of personalized therapeutic strategies for KOA and identifies preliminary possible targets for curcumin.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.