ArticleMedicine2025
Effect of the gut microbiota on frozen shoulder and potential mediating role of inflammatory cytokines: A Mendelian randomization study and mediation analysis.
Article in Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Frozen shoulder (FS), characterized by chronic inflammation and joint fibrosis, remains etiologically unclear. Emerging evidence suggests that gut microbiota may modulate systemic inflammation via the "gut-joint axis," yet causal links to FS are unverified. This study aimed to investigate GM-FS causality using Mendelian randomization and explore inflammatory cytokines as potential mediators. This study was conducted using genome-wide association study data from MiBioGen and IEU. Six cytokines were included in the mediation analysis. Inverse variance weighted served as the primary method, supplemented by weighted median and MR-Egger, with sensitivity analyses to ensure robustness. Among 119 bacterial genera, Butyrivibrio (OR = 0.922), Lachnospiraceae UCG004 (OR = 0.897), Lactobacillus (OR = 0.843), Parabacteroides (OR = 0.790), and Ruminococcaceae UCG003 (OR = 0.836) are protective against FS, while Eubacterium coprostanoligenes (OR = 1.172) is a risk factor (all P < .05). Mediation analysis revealed interferon -γ partially mediated the protective effect of Lactobacillus on FS (β = 0.170, P = .011). These findings advance the "gut-joint axis" theory and suggest novel therapeutic targets for FS, deserving further experimental validation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.