ArticleMedicine2025
Genetically predicted mood disorders increased risk of cisplatin-induced hearing loss in childhood cancer: Evidence from a bidirectional Mendelian randomization study.
Article in Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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7 authors.
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Abstract
Children with cancer often suffer from hearing loss caused by cisplatin, which is often accompanied by more frequent mood swings. However, the causal relationship between the 2 remains unclear. This study investigated whether mood swings have a causal effect on cisplatin-induced hearing loss in childhood cancer. We obtained genome-wide association data for mood swings and cisplatin-induced hearing loss in childhood cancer from the Mendelian randomization (MR) base platform. Significant single nucleotide polymorphisms associated with mood swings were used as instrumental variables in 2-sample MR analyses. The causal relationship was examined using the inverse-variance weighted method, weighted median estimator, and MR-Egger regression. A total of 40 single nucleotide polymorphisms significantly linked to mood swings (P < 5 × 10-8; linkage disequilibrium r2 < 0.001) were identified. All methods consistently indicated a positive association between mood swings and cisplatin-induced hearing loss (inverse-variance weighted: odds ratio [OR]: 445.531, 95% confidence interval [CI]: 14.667-13533.950; weighted median: OR: 203.819, 95% CI: 2.113-19663.482; MR-Egger: OR: 100.431, 95% CI: 10-7 to 1010). In contrast, no causal effect was found for genetic predisposition to cisplatin-induced hearing loss on mood swings. The findings provide strong evidence that frequent mood swings may causally increase the risk of cisplatin-induced hearing loss in childhood cancer.
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