ArticleMedicine2025
The causal effect between psoriasis and male reproductive health, and the mediating effect of serum inflammatory factors and metabolites.
Article in Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
The relationship between psoriasis and male reproductive health has sparked extensive research. But the causal relationship and direction remain unknown. To examine the causal association between psoriasis and male reproductive health, and to investigate the role of serum inflammatory factor and metabolites as mediators. A 2-step Mendelian randomization analysis was utilized. Inverse variance weighted method to explore the causal effects. The Cochran Q test was employed to assess the heterogeneity. The Mendelian randomization-Egger and Mendelian randomization-PRESSO method was used to explore the genetic pleiotropy. The mediating effects can be verified using a stepwise testing approach. Psoriasis vulgaris (P = .005, odds ratios [OR] = 1.137), arthropathic psoriasis (P = .044, OR = 1.112), guttate psoriasis (P = .026, OR = 1.041), and other and unspecified psoriasis (P = .030, OR = 1.085) were found to be risk factors for abnormal spermatozoa. X-09026 (49.219%) and macrophage migration inhibitory factor (18.000%) serve as mediators in the regulation of the causal association between Psoriasis vulgaris and abnormal spermatozoa. Methylcysteine (35.849%) also acts as a mediator in the regulation of the causal relationship between arthropathic psoriasis and abnormal spermatozoa. Psoriasis may cause sperm abnormality through metabolites such as X-09026, macrophage migration inhibitory factor, and methylcysteine.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.