ArticleMedicine2025
Multi-target pharmacological mechanisms of Iris tectorum Maxim. (CSG) against tonsillitis and dyspepsia: A network pharmacology approach.
Article in Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Iris tectorum Maxim. (CSG) is a notable traditional Chinese medicinal herb recognized for its broad pharmacological activities, indicating potential therapeutic effects in treating tonsillitis and dyspepsia. This study employed a network pharmacology approach to elucidate the shared mechanisms of CSG in the treatment of tonsillitis and dyspepsia. First, potential targets of CSG were predicted. Second, disease-related genes for tonsillitis and dyspepsia were retrieved from public databases. Third, a protein-protein interaction network was constructed and analyzed using gene ontology and Kyoto encyclopedia of genes and genomes. Finally, molecular docking was performed to validate key targets. The main active components of CSG included tectoridin, tectorigenin, rhamnocitrin, and rhamnazin, with 1148 key targets identified. We found 14 shared target genes between CSG and the 2 diseases. Using Cytoscape for analysis, we created a network diagram with 66 nodes. Molecular docking revealed that serine/threonine-protein kinase 1, mitogen-activated protein kinase 1, epidermal growth factor receptor, vascular endothelial growth factor A, and phosphoinositide-3-kinase regulatory subunit 1 are likely involved in CSG's multi-target effects. The potential pathways of CSG in treating tonsillitis and dyspepsia involve the regulation of endogenous deoxyribonuclease activity, nucleotide excision repair, and DNA damage recognition, among other biological processes. These findings suggest that CSG's potential effects on tonsillitis and dyspepsia may involve multi-compound, multi-target, and multi-pathway mechanisms, providing preliminary mechanistic insights for future research.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.