ArticleMedicine2025
Use of bidirectional Mendelian randomization to unveil the association of Helicobacter pylori infection and pancreatic cancer.
Article in Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
3 authors.
Funding
Abstract
Helicobacter pylori (H pylori), a common gram-negative bacterium and known carcinogen, causes chronic infection. Recent studies suggest its link to extra-gastric cancers, including pancreatic cancer, but conflicting findings due to confounding factors hinder clear association. Using summary-level data from genome-wide association studies, we analyzed the bidirectional causal relationship between H pylori-related antibody-mediated immune responses and pancreatic cancer. We further validated the results using generalized summary-data-based Mendelian randomization (GSMR). We found that the levels of H pylori outer membrane protein (OMP) antibody can significantly increase the risk of pancreatic cancer (OR: 1.8122, 95% CI: 1.3192-2.4894, P < .001). These results were consistent with the weighted median algorithm (OR: 1.9638, 95% CI: 1.2686-3.0399, P = .002). Furthermore, the results from GSMR were also consistent with the above results (OR: 1.7099, 95% CI: 1.2632-2.3144, P < .001). Elevated H pylori OMP antibody levels are associated with increased pancreatic cancer risk. OMP may serve as a potential vaccine target for future prevention strategies.
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