Evidence map›Paper›PMID 41029024›Full record

ArticleCombinatorial chemistry & high throughput screening2026

YBX1 Enhances the Stability of TM4SF1 in an m

Hong Li, Yu Liang, Jian Tang, Hongmei Luo, Yi Wang

Abstract read
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In one paragraph

Article in Combinatorial chemistry & high throughput screening, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Hong LiDepartment of Urology, The Second Affiliated Hospital, Hengyang Medical School, University of South China, 421001 Hengyang, 421001, China.
Yu LiangDepartment of Urology, Pingxiang City People's Hospital, Pingxiang, 337000, China.
Jian TangDepartment of Urology, The Second Affiliated Hospital, Hengyang Medical School, University of South China, 421001 Hengyang, 421001, China.
Hongmei LuoDepartment of Histology and Embryology, Hengyang Medical School, University of South China, Hengyang, 421001, China.
Yi WangDepartment of Urology, The Second Affiliated Hospital, Hengyang Medical School, University of South China, 421001 Hengyang, 421001, China.

Funding

Basic Research of Hengyang Science and Technology Bureau 2018KJ135Hengyang Science and Technology Plan Project 202250045386
6 · The paper itself

Abstract

introductionY-box binding protein 1 (YBX1), an RNA-binding protein capable of recognizing the 5-methylcytosine (m

methodsThe impact of YBX1 on glycolysis and biological functions in BCa cells was evaluated through a set of in vitro experiments. The underlying mechanisms involving YBX1, Transmembrane 4 L six family 1 (TM4SF1), and β-catenin/C-myc in BCa and their relationship were investigated using RNA immunoprecipitation (RIP), m

resultsBCa cells exhibited elevated expression levels of YBX1 compared to human transitional bladder epithelial cells. YBX1 knockdown inhibited BCa cell proliferation, migration, and invasion while also attenuating glycolytic activity, as evidenced by reduced glucose uptake, lactic acid production, and ATP synthesis. Mechanically, we found that YBX1-dependent m DISCUSSION: This study has refined the mechanism of BCa progression, but the clinical significance and in vivo functions of the YBX1/TM4SF1 axis still require further verification.

conclusionYBX1 stabilizes TM4SF1 mRNA via m

Indexed as

GlycolysisNeoplasm ProteinsUrinary Bladder NeoplasmsY-Box-Binding Protein 1Antigens, SurfaceCell Line, TumorCell ProliferationHumansAntigens, SurfaceNeoplasm ProteinsTM4SF1 protein, humanY-Box-Binding Protein 1YBX1 protein, humanBladder cancerglycolysismproliferationTM4SF1YBX1

Identifiers

PMID41029024

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.