Evidence map›Paper›PMID 41028928›Full record

ReviewActa obstetricia et gynecologica Scandinavica2025

Parvovirus: Conservative management of fetal anemia and hydrops.

Lyndsay Creswell, Pranav Pandya, Daniel Stott, Donald Peebles, George Attilakos, Eleni Nastouli, Haley Alchin, Kelly Pegoretti Baruteau, Raffaele Napolitano

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Acta obstetricia et gynecologica Scandinavica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Parvovirus: Conservative management of fetal anemia and hydrops.Acta obstetricia et gynecologica Scandinavica · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Lyndsay CreswellFetal Medicine Unit, University College London Hospitals NHS Foundation Trust, London, UK.ORCID 0009-0006-7407-4493
Pranav PandyaFetal Medicine Unit, University College London Hospitals NHS Foundation Trust, London, UK.
Daniel StottFetal Medicine Unit, University College London Hospitals NHS Foundation Trust, London, UK.ORCID 0000-0002-5207-5560
Donald PeeblesFetal Medicine Unit, University College London Hospitals NHS Foundation Trust, London, UK.
George AttilakosFetal Medicine Unit, University College London Hospitals NHS Foundation Trust, London, UK.
Eleni NastouliDepartment of Infection, Immunity and Inflammation, University College London, Great Ormond Street Institute of Child Health, London, UK.
Haley AlchinDepartment of Clinical Virology, University College London Hospitals, NHS Foundation Trust, London, UK.
Kelly Pegoretti BaruteauLysholm Department of Neuroradiology, University College London Hospitals NHS Foundation Trust, London, UK.
Raffaele NapolitanoFetal Medicine Unit, University College London Hospitals NHS Foundation Trust, London, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Following the COVID-19 pandemic, Northwestern Europe has experienced a marked increase in congenital parvovirus infections. This rise is attributed to social distancing measures which disrupted the usual seasonal variation of parvovirus B19. Fetal infection may cause severe anemia, thrombocytopenia, and hydrops fetalis, with significant risk of intrauterine death. Therefore, when acute parvovirus B19 infection is confirmed by maternal serology, serial ultrasound surveillance of the middle cerebral artery peak systolic velocity is recommended. Intrauterine transfusion remains the only established therapeutic option for cases of suspected fetal anemia or hydrops but carries risks of fetal loss and procedural-related complications including fetal hemorrhage and exsanguination. This review critically examines current literature on diagnosis, management, perinatal outcomes, and long-term neurodevelopmental sequelae following congenital parvovirus infection and intrauterine transfusion. Additionally, we report our tertiary fetal medicine center's experience during the 2024 epidemic, highlighting a novel conservative management approach for fetuses with parvovirus-related anemia and hydrops fetalis.

Indexed as

AnemiaConservative TreatmentFetal DiseasesHydrops FetalisParvoviridae InfectionsPregnancy Complications, InfectiousBlood Transfusion, IntrauterineCOVID-19FemaleHumansParvovirus B19, HumanPregnancyUltrasonography, Prenatalanemiacongenital parvovirusfetal infectionhydrops fetalisintrauterine deathparvovirus B19thrombocytopenia

Identifiers

PMID41028928
PMCPMC12575175

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.