Evidence map›Paper›PMID 41028919›Full record

ArticleNature chemistry2025

Dual dynamic helical poly(disulfide)s with conformational adaptivity and configurational recyclability.

Qi Zhang, Valentin P Nicu, Wybren Jan Buma, He Tian, Da-Hui Qu, Ben L Feringa

Abstract read
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In one paragraph

Article in Nature chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Qi ZhangKey Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, Institute of Fine Chemicals, Frontiers Science Center for Materiobiology and Dynamic Chemistry, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai, China. q.zhang@ecust.edu.cn.ORCID http://orcid.org/0000-0001-8616-5452
Valentin P NicuProvitam Foundation, Cluj-Napoca, Romania.ORCID http://orcid.org/0000-0001-6110-117X
Wybren Jan BumaVan't Hoff Institute for Molecular Sciences, University of Amsterdam, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0002-1265-8016
He TianKey Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, Institute of Fine Chemicals, Frontiers Science Center for Materiobiology and Dynamic Chemistry, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai, China.ORCID http://orcid.org/0000-0003-3547-7485
Da-Hui QuKey Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, Institute of Fine Chemicals, Frontiers Science Center for Materiobiology and Dynamic Chemistry, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai, China. dahui_qu@ecust.edu.cn.ORCID http://orcid.org/0000-0002-2039-3564
Ben L FeringaKey Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, Institute of Fine Chemicals, Frontiers Science Center for Materiobiology and Dynamic Chemistry, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai, China. b.l.feringa@rug.nl.ORCID http://orcid.org/0000-0003-0588-8435

Funding

EC | EU Framework Programme for Research and Innovation H2020 | H2020 Priority Excellent Science | H2020 European Research Council (H2020 Excellent Science - European Research Council) 694345
6 · The paper itself

Abstract

The structural dynamics of biopolymers, such as proteins and DNA, feature the unique combination of simultaneous conformational adaptivity and configurational reversibility. However, it remains challenging to design a synthetic system featuring dynamic covalent bonds with secondary structural folding and full recycling capabilities. Here we present a synthetic covalent polymer, constructed from biologically relevant units (amino acids and disulfides), that can reversibly adapt between disordered and helical conformations and can recycle itself to the original small molecules. This dual dynamic feature arises from the subtle synergy of noncovalent bonds (H bonds) and dynamic covalent bonds within a coupled chemical equilibrium, of which thermodynamics is found to follow a nonlinear van't Hoff equation with nonzero heat capacity change. The covalent polymers show conformational dynamics between structured helices and disordered coils and the ability to convert back to the original monomers. This system demonstrates how dual dynamic function can control helical and recyclable polymer formation.

Identifiers

PMID41028919

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.