ReviewNature chemistry2025
Understanding single-molecule reactions using nanopore-based techniques.
Review in Nature chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Identification and Discrimination of Sulfated and Unsulfated Gut-Hormone Biomarkers in Human Serum by Nanopore.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Nanopipette-DNA-Nanopore Hybrid System for Small Molecule Detection.ChemPlusChem · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
The formation and cleavage of chemical bonds are two fundamental processes in chemistry, and the nature of these bonds determines the physical and chemical properties of a molecule. Real-time observation of chemical bonding at the single-molecule level offers insights into transient intermediates that are normally inaccessible via ensemble measurements. Protein nanopores, with their unique geometries, can be tailored into nanoreactors. Molecular bond-making and -cleavage at the reactive site of a protein nanopore's interior wall can be visualized by monitoring ionic current changes. Therefore, nanopore-based techniques can enhance the understanding of complex binding kinetics and reaction mechanisms. In this Review we summarize recent advances in using biological nanopores as both single-molecule nanoreactors and single-molecule biosensors. The discussion covers the kinetics of single-molecule reactions under nanopore confinement, the strategies for designing biological nanopores and the latest progress in revealing reaction intermediates and pathways at the single-molecule level. Finally, we emphasize unresolved challenges and anticipate future developments in this rapidly evolving field.
Identifiers
41028917What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.