ArticleNpj viruses2025
Unlocking the genomic repertoire of a cultivated megaphage.
Article in Npj viruses, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
- The biology of jumbo phages.Nature communications · 2026Review
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Megaphages are bacteriophages (i.e., phages) with exceptionally large genomes that have been discovered computationally across the globe. To date, all have evaded cultivation except phage G, which we examined with multiomics and artificial intelligence (AI) to resolve its 50-year cultivated history. Phage G is one of the largest phages with a size of >0.6 µm, about half the width of the host cell, and a 499 kbp, non-permuted, linear genome that has, uniquely among known phages, two pairs of ends. Phage G has >650 protein-coding open reading frames (ORFs), with >65% being hypothetical proteins, with the expansive repertoire of auxiliary metabolic genes (AMGs) acquired from its bacterial host, manipulate host sporulation (sspD, RsfA, spoK), and antiviral escape genes (e.g., anti-CBass nuclease and Anti-Pycsar protein). Our study represents a doorway into the complexity of the genomic repertoire of the only cultivated megaphage.
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Registered trials
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