Evidence map›Paper›PMID 41028878›Full record

ArticleScientific reports2025

Comparison of intravaginal and interstitial brachytherapy in cervical cancer after inadvertent hysterectomy: a retrospective study.

Sunil Choudhary, Ankita Pandey, Ankita Singh, Ankur Mourya, Neha Gupta, Syed Mohamed Shajid, Gogul Priean Venkatachalam, Sangita Rai, Sakshi Agarwal, Pitchaikannu Venkatraman and 1 more

Abstract readComparative Study
PubMed Full text at PMC Publisher
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Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Sunil ChoudharyDepartment of Radiotherapy and Radiation Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, 221005, Uttar Pradesh, India.
Ankita PandeyDepartment of Radiation Oncology, Postgraduate Institute of Medical Education & Research, Sector-12, Chandigarh, 160012, India.
Ankita SinghDepartment of Radiotherapy and Radiation Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, 221005, Uttar Pradesh, India.
Ankur MouryaDepartment of Radiotherapy, State Cancer Institute, Cancer Hospital, Netaji Subhash Chandra Bose Medical College, Jabalpur, 482003, Madhya Pradesh, India.
Neha GuptaApex Hospital, Varanasi, 221005, Uttar Pradesh, India.
Syed Mohamed ShajidDepartment of Radiation Oncology, Garud Cancer Hospital, Savedi Road, Savedi, Ahmednagar, 414003, Maharashtra, India.
Gogul Priean VenkatachalamDepartment of Radiotherapy and Radiation Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, 221005, Uttar Pradesh, India.
Sangita RaiDepartment of Obstetrics & Gynaecology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, 221005, Uttar Pradesh, India.
Sakshi AgarwalDepartment of Obstetrics & Gynaecology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, 221005, Uttar Pradesh, India.
Pitchaikannu VenkatramanDepartment of Radiotherapy and Radiation Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, 221005, Uttar Pradesh, India.
Lalit Mohan AggarwalDepartment of Radiotherapy and Radiation Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, 221005, Uttar Pradesh, India. lalitm@bhu.ac.in.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The purpose of this study was to compare intravaginal brachytherapy (IVBT) with interstitial brachytherapy (ISBT) in patients presenting with residual or recurrent disease after inadvertent hysterectomy for cervical cancer. Records of consecutive patients with cervical cancer, registered in the Radiotherapy Outpatient Department (RTOPD) between March 2018 and March 2021, who had inadvertent hysterectomy followed by external beam radiotherapy (EBRT) and IVBT (n = 15) or ISBT (n = 15) were analyzed retrospectively. All the patients received a dose of 45-50 Gy/25 fractions in 5 weeks by EBRT with concurrent cisplatin. A dose of 6 Gy/fraction/week for two consecutive weeks was prescribed at 5 mm from the surface of the vaginal cylinder in the IVBT arm. Patients in the ISBT arm were treated with 6 Gy/fraction for four fractions over two days with Martinez Universal Perineal Interstitial Template (MUPIT). Overall survival (OS) and disease-free survival (DFS) were the primary endpoints. Acute and late toxicities were the secondary endpoints. Median follow-up (FU) was 24.3 months and 32.8 months in the IVBT and ISBT arms respectively. Most of the patients failed within 12-18 months after brachytherapy. The 3-year OS for IVBT and ISBT arms were 54% and 93% respectively (p = 0.011). The 3-year DFS for IVBT and ISBT arms were 42% and 93% respectively(p = 0.023). Both the arms had similar acute & late toxicities. ISBT had significantly better survival outcomes in terms of OS, and DFS with similar toxicity as compared to IVBT in patients with residual or recurrent disease after inadvertent hysterectomy for cervical cancer.

Indexed as

BrachytherapyHysterectomyUterine Cervical NeoplasmsAdultAgedFemaleHumansMiddle AgedNeoplasm Recurrence, LocalRetrospective StudiesTreatment OutcomeBrachytherapyCervical cancerHysterectomyMUPITRadiotherapyRecurrence

Identifiers

PMID41028878
PMCPMC12484820

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