ArticleNature communications2025
Single-nucleus transcriptomics reveal the morphogenesis and artemisinin biosynthesis in Artemisia annua glandular trichomes.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Spatial distribution of marker compounds inHorticulture research · 2026Article
- From Model Plants toPlants (Basel, Switzerland) · 2026Review
- Single-Cell Insights into Medicinal Plant Development and Metabolism.Plants (Basel, Switzerland) · 2026Review
- Advances in single-cell and spatial multi-omics for plant development and stress responses.Plant diversity · 2026Review
- Evaluating Causal Claims in Plant Developmental Metabolism: A When-Where-How Framework.Plants (Basel, Switzerland) · 2026Review
- Non-coding RNA: a new perspective on the regulation of secondary metabolites in medicinal plants.Molecular horticulture · 2026Review
- Comprehensive insights into the development of arabidopsis trichomes by single-nucleus RNA-seq.BMC plant biology · 2026Article
- Multiscale modeling of the spatial structure of stem cells in neuroblastoma patient-derived tumoroids reveals a critical role for a short-range diffusive process.PLoS computational biology · 2026Article
- Cloning and Characterization ofGenes · 2026Article
- Cell-type-specific alkaloid and terpenoid biosynthesis in glandular trichomes: single-cell and spatial transcriptomic perspectives.Frontiers in plant science · 2026Review
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Authors and funding
8 authors.
Funding
Abstract
Artemisinin, the key antimalarial drug, is synthesized in Artemisia annua glandular secretory trichomes (GSTs), yet their development and artemisinin's precise cellular origins are unclear. Utilizing single-nucleus RNA sequencing and spatial transcriptomics, we construct a high-resolution cellular atlas mapping metabolic dynamics across GST development. We define three developmental states: the initiation phase, transcriptional activation of core metabolic pathways establishes fundamental cellular machinery; the intermediate phase, marked lipid metabolism activation with coordinated fatty acid and wax biosynthesis, accompanied by active photosynthetic activity; the terminal differentiation phase, metabolite specialized through spatial compartmentalization of terpenoid and lipid biosynthetic pathways. Notably, we discover that six specific secretory cells within the 10-cell GSTs constitute the primary site for artemisinin production. We identify hundreds of hub genes potentially contributing to trichome development or artemisinin biosynthesis. Overall, this study systematically elucidates GST development and artemisinin biosynthesis, revealing its spatial production mechanism and providing essential cellular and genetic foundations for metabolic engineering and fundamental trichome biology.
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