ArticleNPJ Parkinson's disease2025
Thalamic nuclei volume changes associated with cognitive and motor manifestations of Parkinson's disease.
Article in NPJ Parkinson's disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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Who cites it
4 citing papers in PubMed.
- Bilateral intermittent theta burst stimulation over the primary motor cortex improves motor and affective symptoms via thalamic network reintegration in mid-stage Parkinson's disease.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026Trial
- Iron accumulation in the substantia nigra is linked to functional network connectivity alterations in early-stage Parkinson's Disease: an exploratory study.NPJ Parkinson's disease · 2026Article
- Subregional thalamic atrophy in Progressive Supranuclear Palsy: A machine learning study.NeuroImage. Clinical · 2026Article
- Pulvinar subdivisions and connectivity patterns across primate species: a comparative perspective.Frontiers in neuroanatomy · 2026Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Motor and cognitive symptoms are key features of Parkinson's disease (PD), which typically appear over time as the disease progresses. The thalamus, a central hub within basal ganglia-thalamocortical circuits, plays a crucial role in motor, sensory, and cognitive functions. This study examined thalamic nuclei volume and lateralization in individuals with PD and healthy controls, and explored their associations with cognitive and motor measures using partial least squares analysis. We found that cognitive alterations were linked to volume changes in specific nuclei of the anterior, ventral, medial, and posterior thalamic nuclear groups. Notably, the anteroventral and ventral posterolateral nuclei showed strong associations with the Montreal Cognitive Assessment used to assess mild cognitive impairment. Motor impairment was associated with volume lateralization asymmetries in the centromedian, mediodorsal medial, pulvinar anterior, and pulvinar medial nuclei. These findings underscore the multifaceted role of the thalamus in the motor and cognitive manifestations of this neurodegenerative disorder.
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Registered trials
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