Evidence map›Paper›PMID 41028712›Full record

ArticleNature communications2025

Calmodulin binding is required for calcium mediated TRPA1 desensitization.

Justin H Sanders, Camila Garcia, Kehinde M Taiwo, Gregory Quevedo, Glory A Adekanye, Avnika Bali, Candice E Paulsen

Abstract read
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Justin H SandersDepartment of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, USA.ORCID http://orcid.org/0000-0002-8976-7990
Camila Garcia *Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, USA.ORCID http://orcid.org/0000-0003-0644-3673
Kehinde M Taiwo *Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, USA.
Gregory Quevedo *Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, USA.ORCID http://orcid.org/0000-0002-0573-7357
Glory A AdekanyeDepartment of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, USA.
Avnika BaliDepartment of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, USA.ORCID http://orcid.org/0000-0001-6921-8196
Candice E PaulsenDepartment of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, USA. candice.paulsen@yale.edu.ORCID http://orcid.org/0000-0001-5317-773X

Funding

Skill Development for Diverse Scientific Careers: A New Course Predoctoral Program in Cellular and Molecular BiologyT32GM007223 · NIGMS · YALE UNIVERSITY · PI BASERGA, SUSAN J · 1985 to 2019
$31.0M
PREDOCTORAL PROGRAM IN BIOPHYSICST32GM008283 · NIGMS · YALE UNIVERSITY · PI XIONG, YONG · 1988 to 2022
$10.5M
Predoctoral Program in BiophysicsT32GM149438 · NIGMS · YALE UNIVERSITY · PI Yong Xiong, Elsa Chui Ying Yan · 2023 to 2026
$2.6M
Molecular mechanisms of TRPA1 regulationR35GM142825 · NIGMS · YALE UNIVERSITY · PI Candice Elaine Paulsen · 2021 to 2026
$2.5M
Uncovering the interplay of calcium and calmodulin in regulation of TRPA1F31NS122412 · NINDS · YALE UNIVERSITY · PI SANDERS, JUSTIN · 2022 to 2023
$94k
NIGMS NIH HHS R35 GM142825NIGMS NIH HHS T32 GM007223NIGMS NIH HHS T32 GM008283NIGMS NIH HHS T32 GM149438NINDS NIH HHS F31 NS122412U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) R35GM142825U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) T32GM008283U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) T32GM149438U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) 1F31NS122412
6 · The paper itself

Abstract

TRPA1 is an essential calcium (Ca

Indexed as

CalciumCalmodulinTRPA1 Cation ChannelAnimalsBinding SitesHEK293 CellsHumansMiceProtein BindingCalciumCalmodulinTRPA1 Cation ChannelTRPA1 protein, human

Identifiers

PMID41028712
PMCPMC12485084

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.