Preparation of Size-Defined PEG-Grafted Copolymers as a Polymeric Nanoruler for Size Optimization in Passive Targeting.

Yukine Ishibashi, Mitsuru Naito, Chun Yin Jerry Lau, Yoshitsugu Aoki, Kanjiro Miyata

Abstract read

In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

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5 · Who and what money

Authors and funding

5 authors.

Yukine IshibashiDepartment of Materials Engineering, Graduate School of Engineering, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.

Mitsuru NaitoDepartment of Materials Engineering, Graduate School of Engineering, The University of Tokyo, Bunkyo-ku, Tokyo, Japan. naito@rs.tus.ac.jp.

Chun Yin Jerry LauDepartment of Materials Engineering, Graduate School of Engineering, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.

Yoshitsugu AokiDepartment of Molecular Therapy, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan.

Kanjiro MiyataDepartment of Materials Engineering, Graduate School of Engineering, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Size-dependent (or passive) targeting strategies are a major approach for designing nanomedicines (or nanocarriers) that can systemically deliver drugs to lesion sites as well as solid tumors. However, the optimal size range for passive targeting to various noncancerous lesion sites is unclear. Recently, we fabricated poly(ethylene glycol) (PEG)-grafted copolymers (gPEGs) as a size-tunable "polymeric nanoruler" to clarify the optimal size for systemic inflamed/noninflamed muscle tissue targeting. The hydrodynamic diameter (D

Indexed as

Drug CarriersDrug Delivery SystemsNanoparticlesPolyethylene GlycolsPolymersAnimalsMiceMice, Inbred mdxMuscle, SkeletalParticle SizeTissue DistributionDrug CarriersPolyethylene GlycolsPolymersDuchenne muscular dystrophyEPR-like effectMuscle targetingNanomedicineSize-tuning

Identifiers

PMID41028680

DOI10.1016/j.cplett.2008.05.018

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.