ArticleMethods in molecular biology (Clifton, N.J.)2026
Characterization and Phenotypic Assessment of Zebrafish Disease Models for Splice Modulation Studies.
Article in Methods in molecular biology (Clifton, N.J.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Zebrafish has emerged as a powerful model in biomedical research as it recapitulates many human disease pathologies. Zebrafish share approximately 70% evolutionarily conserved genes with humans. Recent advances in genome editing have enabled many precision and inducible models that mimic human disorders to be rapidly generated for phenotypic analysis. The large clutch size, ex vivo development, and ability to uptake drug compounds through their skin and gills during early larvae development make the zebrafish an extremely attractive system for high-throughput drug screening. Here, we describe the generation of zebrafish models for splice modulation studies and general phenotypic assessments in human disease modeling.
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