ArticleAnnals of surgical oncology2026
Iterative Hepatic and Pulmonary Metastasectomy in Stage IV Colorectal Cancer: Impact on Survival and Surgical Outcomes.
Article in Annals of surgical oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Pulmonary Metastasectomy After Liver Transplantation: Indications, Timing, and Surgical Decision-Making Across Primary Tumor Histologies.Diagnostics (Basel, Switzerland) · 2026Review
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Authors and funding
11 authors.
Funding
Abstract
backgroundColorectal cancer frequently metastasizes to the liver and lungs. Despite curative-intent resections, recurrence rates are high. While initial hepatic and pulmonary metastasectomies have been well-studied, data are limited on outcomes following iterative resections for recurrent metastases in both locations.
methodsWe retrospectively assessed the long-term outcome (> 10 years) of 97 patients who underwent iterative hepatic and pulmonary resections for recurrent colorectal cancer metastases.
resultsPost initial hepatic metastasectomy survival rates showed no difference for synchronous and metachronous colorectal liver metastases. Multiple hepatic as well as pulmonary metastasectomies did ameliorate patient survival compared to single resections. Postoperative complications ≥ Clavien Dindo grade II after a second hepatic metastasectomy were associated with reduced overall survival, while complication profiles did not alter survival rates after pulmonal metastasectomies. Importantly, iterative liver and lung surgery did not increase subsequent postoperative complications, with median complication severity remaining at Clavien Dindo grade II-IIIa across successive resections.
conclusionsOur data suggest comparable benefits from hepatic metastasectomy regardless of metastatic sequence. Our findings demonstrate the safety and potential survival benefits of iterative hepatic and pulmonary resections for recurrent colorectal cancer metastases. These data support an aggressive surgical approach in selected patients with recurrent colorectal metastases.
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