SynthesisAnnals of surgical oncology2026
The Prognostic Impact of Imaging Detected Tumor Deposits in Rectal Cancer: A Systematic Review and Meta-analysis.
Synthesis in Annals of surgical oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07345273 (Reporting of Tumour Deposits in Colorectal Cancer by Radiology and Pathology), which is not on this map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Reporting of Tumour Deposits in Colorectal Cancer by Radiology and Pathology
Who cites it
4 citing papers in PubMed.
- Lateral pelvic lymph nodes in rectal cancer: a narrative review.Abdominal radiology (New York) · 2026Review
- MRI assessment of tumour deposits in rectal cancer.European radiology · 2026Article
- Preoperative identification of tumor deposits in rectal cancer using a transformer-based multimodal fusion model: a multicenter retrospective study.BMC medical imaging · 2026Article
- Higher local recurrence as the distinct failure pattern in early-onset rectal cancer: a tailored MRI score to guide therapy.NPJ precision oncology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTumor deposits (TDs) identified at pathology post rectal cancer resection are increasingly recognized as an adverse prognostic factor. Advances in magnetic resonance imaging (MRI) allow for the preoperative detection of TDs (mrTDs), raising the possibility that patients with mrTDs may benefit from neoadjuvant treatment strategies or enhanced surveillance.
objectiveThis meta-analysis primarily aims to evaluate the prognostic significance of mrTDs in rectal cancer patients. We also evaluate the impact of other prognostic features.
methodsA comprehensive search was conducted in MEDLINE, Embase, and Scopus databases. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed. Prognostic endpoints included disease-free survival (DFS) and overall survival (OS). Pooled hazard ratios (HR) were calculated using R software.
resultsOverall, 5813 and 5630 patients were included in the systematic review (13 studies) and meta-analysis (11 studies), respectively. The pooled HR for OS and DFS for mrTDs was 2.1 (95% confidence interval [CI] 1.63-2.70; p < 0.0001) and 2.13 (95% CI 1.68-2.71; p < 0.0001), respectively. The pooled HR for OS and DFS for extramural venous invasion (mrEMVI) and circumferential resection margin (mrCRM) involvement was also significantly increased (p < 0.01). The pooled HR for MRI-predicted nodal disease (mrLNMs) and T stage (mrT) for OS and DFS was insignificant (p > 0.05).
conclusionThis meta-analysis confirms the prognostic significance of mrTDs on OS and DFS in rectal cancer. This was also observed for mrEMVI and mrCRM, but not for mrLNMs or mrT. Current staging using TNM has poor prognostic power. A novel evidence-based staging system is needed to identify high risk patients and guide preoperative treatment strategies. Trial registration The protocol for this study was registered in the PROSPERO database (CRD420251011285).
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