Articlenpj antimicrobials and resistance2025
Relating antimicrobial use to wastewater resistance gene patterns via metagenomic analysis of two neighboring treatment plants circa the COVID-19 pandemic.
Article in npj antimicrobials and resistance, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- Building-Scale Wastewater Metagenomics Reveals Temporal Patterns in Resistance and Virulence Genes.Antibiotics (Basel, Switzerland) · 2026Article
- The COVID-19 pandemic influenced the temporal dynamics of antimicrobial resistance markers and bacterial community across urban wastewater treatment plants.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2026Article
- Effects of Growth Stage and Physiological State on Gut Health, Antioxidant Capacity, and Muscle Nutritional Composition in Greenhouse-CulturedAntioxidants (Basel, Switzerland) · 2026Article
- Antimicrobial Resistance Across the Urban Wastewater Continuum: A One Health Assessment Using High-Throughput qPCR.Antibiotics (Basel, Switzerland) · 2026Article
- Sulfur Oxidation by New and Non-Canonical Bacteria in a Subsurface Flow Constructed Wetland Treating Domestic Wastewater.Microorganisms · 2026Article
- Integrating artificial intelligence with genome sequencing against antimicrobial resistance: a narrative review.Frontiers in public health · 2026Review
Corrections and comments
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Authors and funding
15 authors.
Funding
Abstract
Minimizing antimicrobial use is a recommended strategy to reduce the evolution and spread of antibiotic resistance; however, efficacy is elusive to measure. Wastewater-based surveillance provides a promising means to relate trends in microbial community antibiotic resistance profiles as a function of interventions and other factors. We examined influent sewage metagenomes for two neighboring wastewater treatment plants (WWTPs) serving a university and a nearby community. We compared antibiotic resistance gene (ARG) profiles as a function of diagnoses of COVID-19 and other illnesses, antibiotic use, antibiotic/antimicrobial and disinfectant/quaternary ammonium compound concentrations, and COVID-19-related behavioral shifts. Diversity and abundances of ARGs unique to the corresponding sewage were consistently higher for the community WWTP, but converged in 2022 when antibiotic prescriptions surged in the university zip code. Decreases in ARG diversity/abundance were not apparent during periods of decreased antibiotic usage, indicating that extended times may be required for wastewater ARG signals to attenuate following interventions.
Identifiers
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Registered trials
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