ArticlePediatric research2025
Global, regional, and national burden of digestive congenital anomalies from 1990-2021.
Article in Pediatric research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Temporal trends and maternal factors associated with congenital anomalies among live births in São Paulo, Brazil: a population-based study, 2015-2023.BMC pregnancy and childbirth · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDigestive congenital anomalies (DCAs) are a major cause of neonatal death and disability, but comprehensive data on their global burden and regional disparities are limited. This study aimed to evaluate the global trends and burden of DCAs from 1990 to 2021.
methodsData from Global Burden of Disease Study 2021 were used to estimate annual prevalence, mortality, disability-adjusted life years (DALYs), age-standardized rates (ASPR, ASMR, ASDR) of DCAs. The average annual percent change (AAPC) was calculated and frontier analysis was conducted to evaluate the potential for burden reduction. Future trends were projected using statistical modeling.
resultsBetween 1990 and 2021, the global burden of DCAs decreased significantly, with reductions in mortality and DALYs. ASMRs declined from 1.19 (0.66, 1.85) to 0.77 (0.58, 0.96) per 100,000 (AAPC = -1.40), and ASDRs from 108.30 (60.88, 166.69) to 70.44 (53.14, 87.60) (AAPC = -1.38). The burden was highest in infants aged 0-6 days and in low-SDI regions, which have greater improvement potential. By 2036, prevalent cases will increase, but deaths and DALYs are expected to continue declining.
conclusionsDespite progress in reducing the burden of DCAs, disparities persist, particularly in low-SDI regions, emphasizing the need for improved healthcare and neonatal surgery access. IMPACT: We analyzed global trends in the prevalence, mortality, and DALYs of digestive congenital anomalies (DCAs) from 1990 to 2021 using data from the Global Burden of Disease Study 2021. Our findings reveal that although the global burden of DCAs has declined, significant disparities persist, particularly in low- and middle-SDI regions. Frontier analysis emphasized substantial improvement potential in these regions. These results underscore the urgent need for enhanced screening programs, healthcare resources, and targeted interventions in low-SDI regions to further reduce the burden of DCAs and achieve equitable healthcare outcomes.
Identifiers
41028511What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.